Dok-2 Antibody (A-5): sc-271781
- Dok-2 Antibody (A-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 377-409 at the C-terminus of Dok-2 of human origin
- recommended for detection of Dok-2 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dok-2 Antibody (A-5). This work is in progress.
Dok-2 Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects Dok-2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dok-2, also known as p56 Dok, plays a crucial role in cellular signaling pathways by acting as a docking protein that interacts with various tyrosine kinases, including the oncogenic p210 Bcr-Abl fusion protein associated with chronic myelogenous leukemia. This interaction suggests Dok-2 may be involved in mediating the effects of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF), which are vital for cell proliferation and survival. The structure of Dok-2 includes multiple tyrosine residues and potential SH2 binding sites, which facilitate Dok-2′s role in signal transduction and highlight Dok-2′s importance in regulating cellular responses to external stimuli. Understanding Dok-2′s function and interactions can provide insights into cancer progression mechanisms and potential targeted therapies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dok-2 Antibody (A-5) | sc-271781 | 200 µg/ml | $322.00 | |||
Dok-2 (A-5) Neutralizing Peptide | sc-271781 P | 100 µg/0.5 ml | $69.00 |