Dok-2 Antibody (15): sc-135889
- Dok-2 Antibody (15) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 314-412 of Dok-2 of mouse origin
- recommended for detection of Dok-2 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dok-2 Antibody (15). This work is in progress.
Dok-2 Antibody (15) is a mouse monoclonal IgG1 antibody that detects Dok-2 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Dok-2, also known as p56 Dok, plays a crucial role in cellular signaling pathways, particularly in hematopoietic cells, where Dok-2 acts as a negative regulator of growth factor signaling. Dok-2 is primarily located in the cytoplasm, where Dok-2 interacts with various signaling molecules, including the Bcr-Abl fusion protein, which is implicated in chronic myelogenous leukemia. The ability of Dok-2 to modulate signaling pathways is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Additionally, Dok-2 contains multiple tyrosine residues that can be phosphorylated, allowing Dok-2 to serve as a docking site for other signaling proteins, thereby influencing downstream signaling cascades. The interaction of Dok-2 with other proteins, such as the Ras GTPase activating protein, underscores Dok-2′s importance in regulating cell growth and differentiation. Anti-Dok-2 antibody (15) enables researchers to gain insights into the complex signaling networks that govern cellular responses to growth factors and the potential dysregulation that may lead to disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dok-2 Antibody (15) | sc-135889 | 50 µg/0.5 ml | $322.00 |