Molecular structure of Digitoxin, CAS Number: 71-63-6
Digitoxin (CAS 71-63-6)
See product citations (2)
Alternate Names:
Digitaline
Application:
Digitoxin is a cardiac glycoside
CAS Number:
71-63-6
Purity:
≥92%
Molecular Weight:
764.94
Molecular Formula:
C41H64O13
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Digitoxin is a cardiac glycoside extensively studied in biochemical research for its ability to inhibit the sodium-potassium ATPase enzyme. This inhibition is a key aspect of research into the regulation of intracellular ionic concentrations and the resulting effects on cardiac cell electrophysiology. In botanical studies, Digitoxin is examined for its naturally occurring presence in certain plant species and its role in plant defense mechanisms against herbivores. Additionally, it is a reference compound in analytical assays aimed at detecting and quantifying cardiac glycosides in biological samples. In environmental toxicology, research on Digitoxin may explore its persistence in the environment and its effects on non-target organisms, given its potent activity and potential presence in natural water sources.
Digitoxin (CAS 71-63-6) References
- Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells. | Elbaz, HA., et al. 2012. Toxicol Appl Pharmacol. 258: 51-60. PMID: 22037315
- Digitoxin analogues with improved anticytomegalovirus activity. | Cai, H., et al. 2014. ACS Med Chem Lett. 5: 395-9. PMID: 24900847
- Digitoxin enhances the growth inhibitory effects of thapsigargin and simvastatin on ER negative human breast cancer cells. | Einbond, LS., et al. 2016. Fitoterapia. 109: 146-54. PMID: 26691294
- Digitoxin improves cardiovascular autonomic control in rats with heart failure. | Fardin, NM., et al. 2016. Can J Physiol Pharmacol. 94: 643-50. PMID: 27082032
- Digitoxin increases sensitivity of glioma stem cells to TRAIL-mediated apoptosis. | Shang, Z. and Zhang, L. 2017. Neurosci Lett. 653: 19-24. PMID: 28511914
- Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase α1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation. | Mukhopadhyay, R., et al. 2018. J Virol. 92: PMID: 29321306
- Effects of digitoxin on cell migration in ovarian cancer inflammatory microenvironment. | Trenti, A., et al. 2018. Biochem Pharmacol. 154: 414-423. PMID: 29890142
- Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer. | Pollard, BS., et al. 2019. Front Oncol. 9: 630. PMID: 31428571
- Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats. | Picollo, CT., et al. 2020. J Cardiovasc Pharmacol Ther. 25: 265-272. PMID: 31714152
- The inotropic agent digitoxin strengthens desmosomal adhesion in cardiac myocytes in an ERK1/2-dependent manner. | Schinner, C., et al. 2020. Basic Res Cardiol. 115: 46. PMID: 32556797
- Potential antitumor activity of digitoxin and user-designed analog administered to human lung cancer cells. | Eldawud, R., et al. 2020. Biochim Biophys Acta Gen Subj. 1864: 129683. PMID: 32679249
- Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. | Lei, Y., et al. 2020. Oncol Lett. 20: 71. PMID: 32863904
- Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. | Mi, C., et al. 2022. Chem Biol Interact. 351: 109729. PMID: 34717917
- Digitoxin Affects Metabolism, ROS Production and Proliferation in Pancreatic Cancer Cells Differently Depending on the Cell Phenotype. | Lindholm, H., et al. 2022. Int J Mol Sci. 23: PMID: 35897809
- Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial. | Bavendiek, U., et al. 2023. Clin Res Cardiol.. PMID: 37087503
Inhibitor of:
ATP1AL1, Digoxigenin, Dok-2, Na+ CP type Iα, Na+/K+ ATPase β4, Na+/K+-ATPase α1, NKAIN3, sodium/potassium-ATPase α1, and sodium/potassium-ATPase α3.Activator of:
FXYD6, Na+/K+-ATPase α3, and Na+/K+-ATPase α4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Digitoxin, 250 mg | sc-207577 | 250 mg | $112.00 | |||
Digitoxin, 500 mg | sc-207577A | 500 mg | $186.00 | |||
Digitoxin, 1 g | sc-207577B | 1 g | $319.00 | |||
Digitoxin, 5 g | sc-207577C | 5 g | $1102.00 | |||
Digitoxin, 10 g | sc-207577D | 10 g | $2040.00 |