Dhh Antibody (F-8): sc-137101

Dhh Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects Desert hedgehog (Dhh) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dhh is a crucial protein involved in the regulation of cell signaling during embryonic development and tissue patterning, playing a significant role in mediating cell-cell interactions. Dhh is secreted and functions as a morphogen, influencing the fate of neighboring cells by forming gradients that guide developmental processes. Dhh is known to interact with specific receptors, such as Patched and Smoothened, which are essential for transducing the hedgehog signaling pathway. This pathway is vital for various developmental processes, including limb formation and neural patterning, and its dysregulation has been implicated in several cancers and developmental disorders. Anti-Dhh antibody (F-8) provides a reliable tool for researchers studying the intricate roles of hedgehog proteins in development and disease, enabling the exploration of their functions and interactions in various biological contexts.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

Dhh Antibody (F-8) References:

1. Control of sex development.  |  Biason-Lauber, A. 2010. Best Pract Res Clin Endocrinol Metab. 24: 163-86. PMID: 20541146
2. Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases.  |  Krastanova, I., et al. 2012. J Biol Chem. 287: 4121-8. PMID: 22147708
3. Serum level of desert hedgehog protein in autism spectrum disorder: preliminary results.  |  Bashir, S., et al. 2014. Med Princ Pract. 23: 14-7. PMID: 24009062
4. Leydig cell stem cells: Identification, proliferation and differentiation.  |  Chen, H., et al. 2017. Mol Cell Endocrinol. 445: 65-73. PMID: 27743991
5. Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase.  |  Wang, F., et al. 2018. Biochem J. 475: 191-205. PMID: 29203646
6. GATA4/6 regulate DHH transcription in rat adrenocortical autografts.  |  Yoshida, T., et al. 2020. Sci Rep. 10: 446. PMID: 31949236
7. Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.  |  Hollier, PL., et al. 2021. Cardiovasc Res. 117: 2489-2501. PMID: 33063110
8. Dhh-expressing Schwann cell precursors contribute to skin and cochlear melanocytes, but not to vestibular melanocytes.  |  Bonnamour, G., et al. 2021. Pigment Cell Melanoma Res. 34: 648-654. PMID: 33089656
9. Generation of Conditional Knockout Alleles for PRUNE-1.  |  Wu, X., et al. 2023. Cells. 12: PMID: 36831191
10. Neuroimaging in PRUNE1 syndrome: a mini-review of the literature.  |  Scorrano, G., et al. 2023. Front Neurol. 14: 1301147. PMID: 38178891

The preferred Dhh antibody is Dhh Antibody (F-9): sc-271168.