Cytokeratin 10 Antibody (4A27): sc-70907
- Cytokeratin 10 Antibody (4A27) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against Cytokeratins from the human epidermis
- recommended for detection of Cytokeratin 10 of mouse, rat, human and canine origin by WB, IP and IF
- See Cytokeratin 10 (LH2): sc-53252 for Cytokeratin 10 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cytokeratin 10 Antibody (4A27) for WB applications. These reagents are now offered in bundles with Cytokeratin 10 Antibody (4A27) (see ordering information below).
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Cytokeratin 10 Antibody (4A27) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 10 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cytokeratin 10 forms a heterotetramer with keratin 1 as a crucial component of the cytoskeleton in epithelial cells, contributing to structural integrity and tissue resilience. Anti-Cytokeratin 10 antibody (4A27) recognizes a protein predominantly expressed in suprabasal layers of the epidermis, including the stratum corneum, playing a vital role in keratinocyte differentiation and skin barrier function maintenance. Cytokeratin 10 (4A27) monoclonal antibody serves as a valuable marker for tissue differentiation in squamous cell carcinomas, aiding in malignant tumor characterization. Anti-Cytokeratin 10 antibody (4A27) enables researchers to explore cellular mechanisms underlying epithelial tissue development and pathology, proving essential for both basic and clinical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 10 Antibody (4A27) References:
- [The evaluation of the relationship between malignancy grade and cytokeratin-10 accumulation in human skin squamous cell carcinoma]. | Osiecka, BJ., et al. 2001. Przegl Lek. 58: 435-8. PMID: 11603178
- Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization. | O'Brien, LM., et al. 2002. Cell Microbiol. 4: 759-70. PMID: 12427098
- Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10. | Walsh, EJ., et al. 2004. J Biol Chem. 279: 50691-9. PMID: 15385531
- Autoantibodies from synovial lesions in chronic, antibiotic treatment-resistant Lyme arthritis bind cytokeratin-10. | Ghosh, S., et al. 2006. J Immunol. 177: 2486-94. PMID: 16888010
- Molecular mimicry between HSP 65 of Mycobacterium leprae and cytokeratin 10 of the host keratin; role in pathogenesis of leprosy. | Singh, I., et al. 2012. Cell Immunol. 278: 63-75. PMID: 23121977
- Cytokeratin 10 (CK10) expression in cancer: A tissue microarray study on 11,021 tumors. | Uhlig, R., et al. 2022. Ann Diagn Pathol. 60: 152029. PMID: 36029589
- Clinicopathological comparison and cytokeratin-10 expression between Lichen planus and oral lichenoid lesions. | Moreira, MD., et al. 2024. Arch Oral Biol. 171: 106166. PMID: 39742549
- Expression of cytokeratin 10, 13, and involucrin as prognostic factors in low stage squamous cell carcinoma of the uterine cervix. | van Bommel, PF., et al. 1994. Cancer. 74: 2314-20. PMID: 7522949
- Evaluation of laminin and cytokeratin-10 expression in squamous cell carcinoma of the skin. | Osiecka, BJ., et al. 1997. Folia Histochem Cytobiol. 35: 121-2. PMID: 9151104
- Localization of cytokeratin 10 mRNA in human epidermis using nonradioactive in situ hybridization as a routine method. | Meinhold-Heerlein, I., et al. 1998. Arch Dermatol Res. 290: 286-8. PMID: 9681682
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 10 Antibody (4A27) | sc-70907 | 200 µg/ml | $322.00 | |||
Cytokeratin 10 Antibody (4A27): m-IgG Fc BP-HRP Bundle | sc-539319 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cytokeratin 10 Antibody (4A27): m-IgG1 BP-HRP Bundle | sc-541407 | 200 µg Ab; 20 µg BP | $361.00 |