cyclin A Antibody (E43.2): sc-53229
- cyclin A Antibody (E43.2) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against human cyclin A
- recommended for detection of cyclin A of mouse, rat and human origin by WB, IP and IF
- See cyclin A (B-8): sc-271682 for cyclin A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for cyclin A Antibody (E43.2) for WB applications. These reagents are now offered in bundles with cyclin A Antibody (E43.2) (see ordering information below).
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Cyclin A Antibody (E43.2) is a mouse monoclonal IgG2a antibody that detects cyclin A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cyclin A plays a pivotal role in the regulation of the eukaryotic cell cycle, particularly during the S phase, where cyclin A is crucial for the proper progression and timing of DNA replication. Anti-cyclin A antibody (E43.2) targets a protein primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinase-2 (Cdk2) to form active complexes that drive the cell cycle forward. Precise regulation of cyclin A is essential, as dysregulation can lead to uncontrolled cell proliferation and has been implicated in various cancers. Cyclin A also interacts with other key regulatory proteins, including E1A, transcription factors DRTF1 and E2F, and the retinoblastoma protein, p110, highlighting cyclin A′s importance in cell cycle control and transcriptional regulation. Anti-cyclin A antibody (E43.2) serves as an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation and transformation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin A Antibody (E43.2) References:
- Cyclin A correlates with the sensitivity of human cancer cells to cytotoxic effects of 5-FU. | Kawashima, R., et al. 2004. Int J Oncol. 24: 273-8. PMID: 14719102
- Noncatalytic requirement for cyclin A-cdk2 in p27 turnover. | Zhu, XH., et al. 2004. Mol Cell Biol. 24: 6058-66. PMID: 15199159
- Requirements of cyclin a for mitosis are independent of its subcellular localization. | Dienemann, A. and Sprenger, F. 2004. Curr Biol. 14: 1117-23. PMID: 15203007
- Cyclin A probes by means of intermolecular sensitization of terbium-chelating peptides. | Pazos, E., et al. 2008. J Am Chem Soc. 130: 9652-3. PMID: 18593119
- Knocking-down cyclin A(2) by siRNA suppresses apoptosis and switches differentiation pathways in K562 cells upon administration with doxorubicin. | Wang, X., et al. 2009. PLoS One. 4: e6665. PMID: 19684852
- Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila. | Chen, D., et al. 2009. Development. 136: 4133-42. PMID: 19906849
- Acetylation of cyclin A: a new cell cycle regulatory mechanism. | Mateo, F., et al. 2010. Biochem Soc Trans. 38: 83-6. PMID: 20074040
- APOLLON protein promotes early mitotic CYCLIN A degradation independent of the spindle assembly checkpoint. | Kikuchi, R., et al. 2014. J Biol Chem. 289: 3457-67. PMID: 24302728
- Ion Mobility Mass Spectrometry Measures the Conformational Landscape of p27 and its Domains and how this is Modulated upon Interaction with Cdk2/cyclin A. | Beveridge, R., et al. 2019. Angew Chem Int Ed Engl. 58: 3114-3118. PMID: 30570821
- Cyclin A is a reliable proliferation marker in endometrial cancer cell lines. | Horie, K., et al. 2019. Oncol Lett. 17: 4455-4462. PMID: 30988814
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin A Antibody (E43.2) | sc-53229 | 200 µg/ml | $322.00 | |||
cyclin A Antibody (E43.2): m-IgG Fc BP-HRP Bundle | sc-538980 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin A Antibody (E43.2): m-IgG2a BP-HRP Bundle | sc-546655 | 200 µg Ab; 10 µg BP | $361.00 |