Molecular structure of Coumarin-SAHA
Coumarin-SAHA (CAS 1260635-77-5)
Alternate Names:
Coumarin Suberoylanilide Hydroxamic Acid; N1-Hydroxy-N8-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)octanediamide
Application:
Coumarin-SAHA is a fluorescent probe that competitively binds HDAC
CAS Number:
1260635-77-5
Molecular Weight:
346.38
Molecular Formula:
C18H22N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Coumarin-SAHA is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8. This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Coumarin-SAHA, 1 mg | sc-391815 | 1 mg | $56.00 | |||
Coumarin-SAHA, 10 mg | sc-391815A | 10 mg | $216.00 |