Molecular structure of Cochlioquinone A, CAS Number: 32450-25-2
Cochlioquinone A (CAS 32450-25-2)
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Application:
Cochlioquinone A is an antagonist of CKR-5 (CCR5)
CAS Number:
32450-25-2
Purity:
>99%
Molecular Weight:
532.7
Molecular Formula:
C30H44O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. It has been found to be an antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). It is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADHubiquinone reductase.
Cochlioquinone A (CAS 32450-25-2) References
- Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola. | Jung, HJ., et al. 2003. Bioorg Med Chem. 11: 4743-7. PMID: 14556789
- Antimicrobial compounds of fungi vectored by Clusia spp. (Clusiaceae) pollinating bees. | Bicalho, B., et al. 2003. Z Naturforsch C J Biosci. 58: 746-51. PMID: 14577643
- Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1. | Lee, HB., et al. 2003. J Antibiot (Tokyo). 56: 967-9. PMID: 14763563
- The sperm penetration test (P-test) can predict fecundability in the male partner from infertile couples. | Bostofte, E., et al. 1992. Andrologia. 24: 125-9. PMID: 1503248
- Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum. | Yoganathan, K., et al. 2004. J Antibiot (Tokyo). 57: 59-63. PMID: 15032487
- Leishmanicidal metabolites from Cochliobolus sp., an endophytic fungus isolated from Piptadenia adiantoides (Fabaceae). | Campos, FF., et al. 2008. PLoS Negl Trop Dis. 2: e348. PMID: 19079599
- Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites. | Schaeffer, JM., et al. 1990. J Antibiot (Tokyo). 43: 1179-82. PMID: 2211380
- Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances. | do Nascimento, AM., et al. 2015. World J Microbiol Biotechnol. 31: 1793-800. PMID: 26318306
- Identification of meroterpenoids from Bipolaris victoriae S27 and their potential activity against tumor metastasis and inhibition of the NF-κB signaling pathway. | Feng, L., et al. 2022. Phytochemistry. 200: 113180. PMID: 35427653
- Cochlioquinone A, an inhibitor of diacylglycerol kinase. | Machida, T., et al. 1995. J Antibiot (Tokyo). 48: 1076-80. PMID: 7490210
Inhibitor of:
Angiogenesis, CKR-5, DGAT, and DGK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cochlioquinone A, 500 µg | sc-202109 | 500 µg | $291.00 |