CMPD1 (CAS 41179-33-3)
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The MK2a inhibitor functions by targeting and inhibiting the activity of the MK2a enzyme. This inhibition prevents the phosphorylation of substrates by MK2a, which plays a crucial role in various cellular processes such as inflammation, cell proliferation, and stress response. By blocking the activity of MK2a, the inhibitor disrupts the downstream signaling pathways that are regulated by this enzyme. This disruption ultimately leads to the modulation of cellular responses and gene expression. The mechanism of action involves the binding of the inhibitor to the active site of MK2a, thereby preventing its interaction with its substrates. This interference at the molecular level results in the inhibition of MK2a-mediated cellular processes, making the inhibitor useful for studying the specific functions and pathways regulated by MK2a in experimental applications.
CMPD1 (CAS 41179-33-3) References
- Catalysis and function of the p38 alpha.MK2a signaling complex. | Lukas, SM., et al. 2004. Biochemistry. 43: 9950-60. PMID: 15287722
- Discovery and characterization of a substrate selective p38alpha inhibitor. | Davidson, W., et al. 2004. Biochemistry. 43: 11658-71. PMID: 15362850
- MAPK-activated protein kinase 2 is required for mouse meiotic spindle assembly and kinetochore-microtubule attachment. | Yuan, J., et al. 2010. PLoS One. 5: e11247. PMID: 20596525
- Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. | Phoa, AF., et al. 2015. Biochem Pharmacol. 98: 587-601. PMID: 26519552
- Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. | Gurgis, F., et al. 2015. Cell Death Discov. 1: 15028. PMID: 27551460
- CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest. | Li, Y., et al. 2018. Biol Res. 51: 11. PMID: 29661232
- iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. | Dannenmann, B., et al. 2021. Cell Stem Cell. 28: 906-922.e6. PMID: 33894142
- MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway. | Mamidi, P., et al. 2021. PLoS Pathog. 17: e1009667. PMID: 34780576
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CMPD1, 10 mg | sc-203138 | 10 mg | $255.00 |