CIL-102 (CAS 479077-76-4)
Alternative Namen:
1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone
Anwendungen
CIL-102 is an inhibitor of Tubulin polymerization
CAS Nummer:
479077-76-4
Reinheit:
≥95%
Molekulargewicht:
302.33
Summenformel:
C19H14N2O2
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.
Literaturhinweise
- CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line. | Huang, YT., et al. 2005. J Biol Chem. 280: 2771-9. PMID: 15536083
- Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. | Tseng, CH., et al. 2008. Bioorg Med Chem. 16: 3153-62. PMID: 18180162
- Synthesis and antiproliferative evaluations of certain 2-phenylvinylquinoline (2-styrylquinoline) and 2-furanylvinylquinoline derivatives. | Chang, FS., et al. 2010. Bioorg Med Chem. 18: 124-33. PMID: 19944612
- Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives. | Tseng, CH., et al. 2011. Bioorg Med Chem. 19: 7653-63. PMID: 22079254
- The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK. | Teng, CC., et al. 2012. Toxicol Appl Pharmacol. 263: 73-80. PMID: 22683510
- CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells. | Gireesh, KK., et al. 2012. Biochem Pharmacol. 84: 633-45. PMID: 22705644
- CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. | Liu, WH., et al. 2012. Int J Biochem Cell Biol. 44: 2212-22. PMID: 22964005
- Quantitative proteomic analysis of the inhibitory effects of CIL-102 on viability and invasiveness in human glioma cells. | Teng, CC., et al. 2013. Toxicol Appl Pharmacol. 272: 579-90. PMID: 23891858
- Discovery of Novel N-alkyl 4-anilinofuro[2,3-b]quinoline Derivatives (CIL-102 Derivatives) Against Castration-resistant Human Prostate Cancers. | Lo, WF., et al. 2015. Anticancer Agents Med Chem. 15: 493-500. PMID: 25612680
- CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. | Huang, WS., et al. 2017. PLoS One. 12: e0168989. PMID: 28068431
- Novel CIL-102 derivatives as potential therapeutic agents for docetaxel-resistant prostate cancer. | Miller, DR., et al. 2018. Cancer Lett. 436: 96-108. PMID: 30077739
- Novel regulator role of CIL-102 in the epigenetic modification of TNFR1/TRAIL to induce cell apoptosis in human gastric cancer. | Teng, CC., et al. 2021. Food Chem Toxicol. 147: 111856. PMID: 33246054
- Identification of Two Novel CIL-102 Upregulations of ERP29 and FUMH to Inhibit the Migration and Invasiveness of Colorectal Cancer Cells by Using the Proteomic Approach. | Cheng, KC., et al. 2021. Biomolecules. 11: PMID: 34572494
Aggregatzustand
:
Solid
Löslichkeit
:
Soluble in DMSO (12 mg/ml).
LAGERUNG:
:
Store at -20° C
Schmelztemperatur
:
196.39° C (Predicted)
Sidepunkt
:
~498.5° C at 760 mmHg (Predicted)
Dichte
:
~1.3 g/cm3 (Predicted)
Brechungsindex
:
n20D 1.72 (Predicted)
pK Werte
:
pKb: 0.96 (Predicted)
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK
:
3
PubChem CID
:
MDL-Nummer
:
MFCD08277043
SMILES
:
CC(=O)C1=CC=C(C=C1)NC2=C3C=COC3=NC4=CC=CC=C42
SDS (MSDS) herunterladen
SAMPLE Certificate of Analysis (COA)
CIL-102 | CAS 479077-76-4 SAMPLE Certificate of AnalysisAnalysenzertifikat
SAMPLE Certificate of Analysis (COA)
Catalog Number:sc-214722
Lot Number:SAMPLE
Product Name:CIL-102
Molecular Formula:C19H14N2O2
Molecular Weight:302.33
| Test | Specification | Results |
|---|---|---|
| Appearance | Yellow solid | |
| Identification (1H-NMR) | Consistent with structure | |
| Purity (HPLC) | 97.6% | |
| Molecular Weight | Complies (by Mass spectrometry) | |
| Solubility | Clear solution at 12 mg/ml in dimethyl sulfoxide | |
| Carbon Content | 73.58% | |
| Hydrogen Content | 4.60% | |
| Nitrogen Content | 9.01% | |
| Water Content (CHN) | 0.5 mole/mole |
TEST CONDITIONS
Exp. Date: 11/13/2023