CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.
|Identification (1H-NMR)||Consistent with structure|
|Molecular Weight||Complies (by Mass spectrometry)|
|Solubility||Clear solution at 12 mg/ml in dimethyl sulfoxide|
|Water Content (CHN)||0.5 mole/mole|
Exp. Date: 11/13/2023