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CIL-102 | CAS 479077-76-4 | SCBT - Santa Cruz Biotechnology
CIL-102 CAS: 479077-76-4
MF: C19H14N2O2
MW: 302.33
CIL-102 is an inhibitor of Tubulin polymerization.

CIL-102 (CAS 479077-76-4)

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Alternative Namen: 1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone
Anwendungen CIL-102 is an inhibitor of Tubulin polymerization
CAS Nummer: 479077-76-4
Reinheit: ≥95%
Molekulargewicht: 302.33
Summenformel: C19H14N2O2
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
* Schauen Sie auf das Analysezertifikat (CoA), um die genauen Daten (inkl. Wassergehalt) Ihrer Produktionscharge (Lot) zu sehen.

CIL-102 is a semisynthetic alkaloid derivative, which inhibits cell growth in a wide variety of cancer cell lines in a dose dependent manner. Studies conducted with Immunofluorescence microscopy suggest that CIL-102 can functions to slow down cell growth by binding to Tubulin, inhibiting Tubulin polymerization and disrupting microtubule organization. In addition, cells accumulate in the presence of CIL-102 in G(2)/M phase and sub-G(0)/G(1) phase. CIL-102 causes apoptosis in PC-3 cells via activation of caspase-3 and slows down cell growth by modulating cyclin-dependent kinases.


  1. CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.  |  Huang, YT., et al. 2005. J Biol Chem. 280: 2771-9. PMID: 15536083
  2. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives.  |  Tseng, CH., et al. 2008. Bioorg Med Chem. 16: 3153-62. PMID: 18180162
  3. Synthesis and antiproliferative evaluations of certain 2-phenylvinylquinoline (2-styrylquinoline) and 2-furanylvinylquinoline derivatives.  |  Chang, FS., et al. 2010. Bioorg Med Chem. 18: 124-33. PMID: 19944612
  4. Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives.  |  Tseng, CH., et al. 2011. Bioorg Med Chem. 19: 7653-63. PMID: 22079254
  5. The inhibitory effect of CIL-102 on the growth of human astrocytoma cells is mediated by the generation of reactive oxygen species and induction of ERK1/2 MAPK.  |  Teng, CC., et al. 2012. Toxicol Appl Pharmacol. 263: 73-80. PMID: 22683510
  6. CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells.  |  Gireesh, KK., et al. 2012. Biochem Pharmacol. 84: 633-45. PMID: 22705644
  7. CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability.  |  Liu, WH., et al. 2012. Int J Biochem Cell Biol. 44: 2212-22. PMID: 22964005
  8. Quantitative proteomic analysis of the inhibitory effects of CIL-102 on viability and invasiveness in human glioma cells.  |  Teng, CC., et al. 2013. Toxicol Appl Pharmacol. 272: 579-90. PMID: 23891858
  9. Discovery of Novel N-alkyl 4-anilinofuro[2,3-b]quinoline Derivatives (CIL-102 Derivatives) Against Castration-resistant Human Prostate Cancers.  |  Lo, WF., et al. 2015. Anticancer Agents Med Chem. 15: 493-500. PMID: 25612680
  10. CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45.  |  Huang, WS., et al. 2017. PLoS One. 12: e0168989. PMID: 28068431
  11. Novel CIL-102 derivatives as potential therapeutic agents for docetaxel-resistant prostate cancer.  |  Miller, DR., et al. 2018. Cancer Lett. 436: 96-108. PMID: 30077739
  12. Novel regulator role of CIL-102 in the epigenetic modification of TNFR1/TRAIL to induce cell apoptosis in human gastric cancer.  |  Teng, CC., et al. 2021. Food Chem Toxicol. 147: 111856. PMID: 33246054
  13. Identification of Two Novel CIL-102 Upregulations of ERP29 and FUMH to Inhibit the Migration and Invasiveness of Colorectal Cancer Cells by Using the Proteomic Approach.  |  Cheng, KC., et al. 2021. Biomolecules. 11: PMID: 34572494

Aggregatzustand :
Löslichkeit :
Soluble in DMSO (12 mg/ml).
Store at -20° C
Schmelztemperatur :
196.39° C (Predicted)
Sidepunkt :
~498.5° C at 760 mmHg (Predicted)
Dichte :
~1.3 g/cm3 (Predicted)
Brechungsindex :
n20D 1.72 (Predicted)
pK Werte :
pKb: 0.96 (Predicted)
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Deutsche WGK :
PubChem CID :
MDL-Nummer :

SDS (MSDS) herunterladen


SAMPLE Certificate of Analysis (COA)

Catalog Number:sc-214722
Lot Number:SAMPLE
Product Name:CIL-102
Molecular Formula:C19H14N2O2
Molecular Weight:302.33
AppearanceYellow solid
Identification (1H-NMR)Consistent with structure
Purity (HPLC)97.6%
Molecular WeightComplies (by Mass spectrometry)
SolubilityClear solution at 12 mg/ml in dimethyl sulfoxide
Carbon Content73.58%
Hydrogen Content4.60%
Nitrogen Content9.01%
Water Content (CHN)0.5 mole/mole


Exp. Date: 11/13/2023

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