Chr-A Antibody (F-12): sc-376827

Chr-A Antibody (F-12) is a mouse monoclonal IgG2b antibody that detects chromogranin A (Chr-A) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Chr-A is a crucial acidic glycoprotein primarily localized within secretory granules of neuroendocrine and endocrine tissues, playing a significant role in the storage and release of hormones and neuropeptides. Elevated levels of Chr-A are often associated with neuroendocrine tumors, making Chr-A a valuable biomarker for diagnosis and monitoring of these conditions. Chr-A (F-12) antibody enables researchers to study Chr-A as a precursor to several biologically active peptides, including pancreastatin, which regulates insulin and gastric acid secretion, highlighting Chr-A′s multifaceted role in endocrine function. Anti-Chr-A antibody (F-12) provides researchers with a reliable tool for studying Chr-A expression and function, facilitating advancements in understanding neuroendocrine signaling and related pathologies.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Chr-A Antibody (F-12) References:

1. Chromogranin A immunoreactivity compared with argyrophilia, calcitonin immunoreactivity, and amyloid as tumour markers in the histopathological diagnosis of medullary (C-cell) thyroid carcinoma.  |  Harach, HR., et al. 1992. Pathol Res Pract. 188: 123-30. PMID: 1594480
2. Chromogranin A as a marker of neuroendocrine histogenesis of tumours: an immunoelectron microscopic study with considerations about the influence of fixation and embedding media on immunolabelling.  |  Leone, BE., et al. 1990. Basic Appl Histochem. 34: 143-53. PMID: 2222401
3. Plasma chromogranin-A in primary hyperparathyroidism.  |  Nanes, MS., et al. 1989. J Clin Endocrinol Metab. 69: 950-5. PMID: 2571619
4. [Chromogranin A derived peptide CGA47-66 inhibits hyper-permeability of blood brain barrier in mice with sepsis].  |  Zeng, Y., et al. 2016. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 28: 122-6. PMID: 26911943
5. Mechanisms involved in the possible protective effect of chrysin against sodium arsenite-induced liver toxicity in rats.  |  Fatemi, I., et al. 2021. Life Sci. 267: 118965. PMID: 33383050
6. Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells.  |  Liu, M., et al. 2021. Int J Mol Sci. 22: PMID: 34202695
7. Chrysomycin A Inhibits the Proliferation, Migration and Invasion of U251 and U87-MG Glioblastoma Cells to Exert Its Anti-Cancer Effects.  |  Liu, DN., et al. 2022. Molecules. 27: PMID: 36234681
8. Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.  |  Liu, DN., et al. 2023. Mar Drugs. 21: PMID: 37367654
9. Tumor protein D52 (isoform 3) induces NF-κB - STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells.  |  Sruthi, KK., et al. 2024. Int J Biochem Cell Biol. 166: 106493. PMID: 37935328
10. Chrysomycin A Reshapes Metabolism and Increases Oxidative Stress to Hinder Glioblastoma Progression.  |  Liu, DN., et al. 2024. Mar Drugs. 22: PMID: 39330272

The preferred Chr-A antibody is Chr-A Antibody (C-12): sc-393941.