Chr-A Antibody (E-5): sc-271738

Chr-A Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects chromogranin A (Chr-A) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Chr-A (E-5) antibody recognizes an acidic glycoprotein predominantly localized within secretory granules of neuroendocrine and endocrine tissues, playing a crucial role in the storage and release of hormones and neuropeptides. Elevated levels of Chr-A are often associated with neuroendocrine tumors, making Chr-A monoclonal antibody (E-5) a valuable tool for diagnosis and monitoring of these malignancies. Chr-A serves as the precursor to several biologically active peptides, including pancreastatin, which regulates insulin and gastric acid secretion, highlighting Chr-A′s importance in metabolic processes. Anti-Chr-A antibody (E-5) effectively identifies Chr-A in various experimental settings, making this antibody an essential tool for researchers studying neuroendocrine function and related pathologies.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Chr-A Antibody (E-5) References:

1. Chromogranin A immunoreactivity compared with argyrophilia, calcitonin immunoreactivity, and amyloid as tumour markers in the histopathological diagnosis of medullary (C-cell) thyroid carcinoma.  |  Harach, HR., et al. 1992. Pathol Res Pract. 188: 123-30. PMID: 1594480
2. Chromogranin A: osmotically active fragments and their susceptibility to proteolysis during lysis of the bovine chromaffin granules.  |  Helle, KB., et al. 1990. Acta Physiol Scand. 138: 565-74. PMID: 2191538
3. Chromogranin A as a marker of neuroendocrine histogenesis of tumours: an immunoelectron microscopic study with considerations about the influence of fixation and embedding media on immunolabelling.  |  Leone, BE., et al. 1990. Basic Appl Histochem. 34: 143-53. PMID: 2222401
4. Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice.  |  Smith, LM., et al. 2014. Bone. 67: 130-8. PMID: 25003813
5. [Chromogranin A derived peptide CGA47-66 inhibits hyper-permeability of blood brain barrier in mice with sepsis].  |  Zeng, Y., et al. 2016. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 28: 122-6. PMID: 26911943
6. Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells.  |  Liu, M., et al. 2021. Int J Mol Sci. 22: PMID: 34202695
7. Chrysomycin A Inhibits the Proliferation, Migration and Invasion of U251 and U87-MG Glioblastoma Cells to Exert Its Anti-Cancer Effects.  |  Liu, DN., et al. 2022. Molecules. 27: PMID: 36234681
8. Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.  |  Liu, DN., et al. 2023. Mar Drugs. 21: PMID: 37367654
9. Chrysomycin A Reshapes Metabolism and Increases Oxidative Stress to Hinder Glioblastoma Progression.  |  Liu, DN., et al. 2024. Mar Drugs. 22: PMID: 39330272
10. Differential expression of the pS2 protein in the human prostate and prostate cancer: association with premalignant changes and neuroendocrine differentiation.  |  Bonkhoff, H., et al. 1995. Hum Pathol. 26: 824-8. PMID: 7635445

The preferred Chr-A antibody is Chr-A Antibody (C-12): sc-393941.