CD68 Antibody (SPM130): sc-52998
- CD68 Antibody (SPM130) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against a subcellular fraction of human alveolar macrophages
- recommended for detection of CD68 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See CD68 (KP1): sc-20060 for CD68 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD68 Antibody (SPM130) for WB and IHC(P) applications. These reagents are now offered in bundles with CD68 Antibody (SPM130) (see ordering information below).
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CD68 Antibody (SPM130) is a mouse monoclonal IgG1 antibody that detects CD68 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD68 is a member of a family of acidic, highly glycosylated lysosomal glycoproteins, which also includes lamp-1 and lamp-2, and plays a crucial role in the immune system. CD68 is primarily located in cytoplasmic granules and the cytoplasm of various non-hematopoietic tissues, such as liver and kidney tubules and glomeruli, as well as on the surface of immune cells like macrophages, monocytes, neutrophils, basophils, and large lymphocytes. CD68 presence on these immune cells serves as a marker for macrophage activation and is involved in the phagocytosis of pathogens and cellular debris, thereby contributing to the body′s defense mechanisms. Additionally, lysosomal glycoproteins like CD68 are essential components of lysosomal membranes, providing structural integrity and protection against degradation by hydrolases, which is vital for maintaining cellular homeostasis and function. Anti-CD68 antibody (SPM130) is an invaluable tool for researchers studying immune responses, cellular signaling, and lysosomal function in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD68 Antibody (SPM130) References:
- Fibrolamellar carcinomas are positive for CD68. | Ross, HM., et al. 2011. Mod Pathol. 24: 390-5. PMID: 21113139
- Refined prognostic role of CD68-positive tumor macrophages in the context of the cellular micromilieu of classical Hodgkin lymphoma. | Tzankov, A., et al. 2010. Pathobiology. 77: 301-8. PMID: 21266828
- Deletion of the murine scavenger receptor CD68. | Song, L., et al. 2011. J Lipid Res. 52: 1542-50. PMID: 21572087
- CD68+ M1 MACROPHAGES IS ASSOCIATED WITH PLACENTAL INSUFFICIENCY UNDER FETAL GROWTH RESTRICTION. | Berezhna, VA., et al. 2021. Wiad Lek. 74: 213-219. PMID: 33813474
- High Infiltration of CD68+/CD163- Macrophages Is an Adverse Prognostic Factor after Neoadjuvant Chemotherapy in Esophageal and Gastric Adenocarcinoma. | Svensson, MC., et al. 2022. J Innate Immun. 14: 615-628. PMID: 35504250
- FOXP3+/CD68+ ratio within the tumor microenvironment may serve as a potential prognostic factor in classical Hodgkin lymphoma. | Zawati, I., et al. 2022. Hum Immunol. 83: 843-856. PMID: 36068099
- CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis. | Chen, Y., et al. 2023. J Pathol Clin Res. 9: 151-164. PMID: 36598153
- The Distribution of Foxp3 and CD68 in Preeclamptic and Healthy Placentas: A Histomorphological Evaluation. | Ersoy Canillioglu, Y., et al. 2023. J Histochem Cytochem. 71: 211-225. PMID: 37070940
- CD68+ and CD8+ immune cells are associated with the growth pattern of somatotroph tumors and response to first generation somatostatin analogs. | Chiloiro, S., et al. 2023. J Neuroendocrinol. 35: e13263. PMID: 37078422
- Infiltration by Intratumor and Stromal CD8 and CD68 in Cervical Cancer. | Dimitrova, P., et al. 2023. Medicina (Kaunas). 59: PMID: 37109686
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD68 Antibody (SPM130) | sc-52998 | 200 µg/ml | $322.00 | |||
CD68 Antibody (SPM130): m-IgG Fc BP-HRP Bundle | sc-536867 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD68 Antibody (SPM130): m-IgGκ BP-HRP Bundle | sc-534035 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD68 Antibody (SPM130): m-IgG1 BP-HRP Bundle | sc-544867 | 200 µg Ab; 20 µg BP | $361.00 |