CD2 Antibody (OX34): sc-53036
- CD2 Antibody (OX34) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against T cell blasts from mixed lymphocyte reactions of rat origin
- recommended for detection of CD2 cell surface antigen of mouse and rat origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (OX34) for WB and IHC(P) applications. These reagents are now offered in bundles with CD2 Antibody (OX34) (see ordering information below).
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CD2 Antibody (OX34) is a mouse monoclonal IgG2a antibody that detects CD2 in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2′s primary function is to mediate cell adhesion through interaction with CD58 ligand, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (OX34) provides a reliable tool for researchers studying T cell activation and immune interactions, making anti-CD2 antibody (OX34) an essential addition to any immunology research toolkit.
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CD2 Antibody (OX34) References:
- Expression of the CD2 molecule on human B lymphoid progenitors. | Muraguchi, A., et al. 1992. Int Immunol. 4: 841-9. PMID: 1384685
- Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies. | Damschroder, MM., et al. 2004. Mol Immunol. 41: 985-1000. PMID: 15302161
- Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2. | Nunes, RJ., et al. 2008. J Immunol. 180: 988-97. PMID: 18178839
- Conformationally constrained peptides from CD2 to modulate protein-protein interactions between CD2 and CD58. | Gokhale, A., et al. 2011. J Med Chem. 54: 5307-19. PMID: 21755948
- Immunosuppression by co-stimulatory molecules: inhibition of CD2-CD48/CD58 interaction by peptides from CD2 to suppress progression of collagen-induced arthritis in mice. | Gokhale, A., et al. 2013. Chem Biol Drug Des. 82: 106-18. PMID: 23530775
- Expression and function of CD2 during murine thymocyte ontogeny. | Yagita, H., et al. 1989. Eur J Immunol. 19: 2211-7. PMID: 2575032
- Glycosylation and Lipids Working in Concert Direct CD2 Ectodomain Orientation and Presentation. | Polley, A., et al. 2017. J Phys Chem Lett. 8: 1060-1066. PMID: 28191954
- Nurse-like cells promote CLL survival through LFA-3/CD2 interactions. | Boissard, F., et al. 2017. Oncotarget. 8: 52225-52236. PMID: 28881725
- Crosslinking CD3 with CD2 using sepharose-immobilized antibodies enhances T lymphocyte proliferation. | Anderson, P., et al. 1988. Cell Immunol. 115: 246-56. PMID: 2900689
- Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation. | Hahn, WC. and Bierer, BE. 1993. J Exp Med. 178: 1831-6. PMID: 7901319
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (OX34) | sc-53036 | 200 µg/ml | $322.00 | |||
CD2 Antibody (OX34): m-IgG Fc BP-HRP Bundle | sc-536874 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (OX34): m-IgGκ BP-HRP Bundle | sc-534042 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD2 Antibody (OX34): m-IgG2a BP-HRP Bundle | sc-547888 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (OX34) FITC | sc-53036 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (OX34) PE | sc-53036 PE | 200 µg/ml | $349.00 |