Bag-1 Antibody (E-12): sc-515529

Bag-1 Antibody (E-12) is a mouse monoclonal IgG2a antibody that detects BAG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAG1 is a critical player in the regulation of apoptosis, functioning as a BCL2-binding protein that enhances the protective effects of BCL2 against cell death. Anti-BAG1 antibody (E-12) recognizes interactions particularly important in modulating apoptotic pathways previously thought to be independent of BCL2. BAG1 can influence the balance between cell survival and death, making BAG1 a significant factor in various physiological and pathological processes, including cancer progression and response to therapy. Understanding BAG1 dynamics and interactions with other proteins provides insights into apoptosis mechanisms and potentially identifies new therapeutic targets for diseases characterized by dysregulated cell death. BAG1 (E-12) antibody serves as an essential tool for scientists investigating these critical cellular processes.

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Bag-1 Antibody (E-12) References:

1. Bag-1 and Bcl-2 gene transfer in malignant glioma: modulation of cell cycle regulation and apoptosis.  |  Roth, W., et al. 2000. Brain Pathol. 10: 223-34. PMID: 10764042
2. The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines.  |  Arhel, NJ., et al. 2003. Int J Cancer. 106: 364-71. PMID: 12845674
3. BAG-1 expression correlates with Bcl-2, p53, differentiation, estrogen and progesterone receptors in invasive breast carcinoma.  |  Tang, SC., et al. 2004. Breast Cancer Res Treat. 84: 203-13. PMID: 15026618
4. Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis.  |  Lee, SS., et al. 2007. Exp Cell Res. 313: 3222-38. PMID: 17662274
5. Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas.  |  Zheng, HC., et al. 2010. Hum Pathol. 41: 724-36. PMID: 20096920
6. Gene silencing of BAG-1 modulates apoptotic genes and sensitizes lung cancer cell lines to cisplatin-induced apoptosis.  |  Liu, H., et al. 2010. Cancer Biol Ther. 9: 832-40. PMID: 20404511
7. Bcl-2 associated anthanogen-1 (Bag-1) expression and prognostic value in pancreatic head and periampullary cancer.  |  van der Zee, JA., et al. 2013. Eur J Cancer. 49: 323-8. PMID: 22939115
8. The Mechanism of CIRP in Regulation of STAT3 Phosphorylation and Bag-1/S Expression Upon UVB Radiation.  |  Sun, W., et al. 2018. Photochem Photobiol. 94: 1234-1239. PMID: 29981150
9. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.  |  Liu, R., et al. 1998. J Biol Chem. 273: 16985-92. PMID: 9642262
10. BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release.  |  Bimston, D., et al. 1998. EMBO J. 17: 6871-8. PMID: 9843493

The preferred Bag-1 antibody is Bag-1 Antibody (3.10G3E2): sc-56003.