Asparagine synthetase Antibody (F-3): sc-376151
- Asparagine synthetase Antibody (F-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-250 mapping at the N-terminal of Asparagine synthetase of human origin
- recommended for detection of Asparagine synthetase of mouse, rat and human origin by WB, IP, IF and ELISA
- See Asparagine synthetase (G-10): sc-365809 for Asparagine synthetase antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Asparagine synthetase Antibody (F-3) for WB applications. These reagents are now offered in bundles with Asparagine synthetase Antibody (F-3) (see ordering information below).
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Asparagine synthetase Antibody (F-3) is a mouse monoclonal IgG2b antibody that detects asparagine synthetase (ASNS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASNS plays a crucial role in amino acid biosynthesis, particularly in the conversion of L-aspartate to L-asparagine via the L-glutamine pathway, which is essential for cellular functions and growth. ASNS is primarily located in the cytoplasm, where ASNS facilitates the synthesis of asparagine, an amino acid vital for protein synthesis and cellular metabolism. ASNS functioning is particularly important in rapidly dividing cells, as asparagine is necessary for nucleotide synthesis and overall cell proliferation. Additionally, ASNS is regulated during the cell cycle, with ASNS expression peaking during the G1 phase, highlighting ASNS significance in cell cycle progression and the maintenance of cellular homeostasis. Anti-ASNS antibody (F-3) is an invaluable tool for researchers studying metabolic pathways, cell cycle regulation, and the role of amino acids in various physiological and pathological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Asparagine synthetase Antibody (F-3) References:
- Asparagine Synthetase deficiency-report of a novel mutation and review of literature. | Gupta, N., et al. 2017. Metab Brain Dis. 32: 1889-1900. PMID: 28776279
- Human asparagine synthetase associates with the mitotic spindle. | Noree, C., et al. 2018. Biol Open. 7: PMID: 30464009
- The role of asparagine synthetase on nutrient metabolism in pancreatic disease. | Tsai, CY., et al. 2020. Pancreatology. 20: 1029-1034. PMID: 32800652
- Asparagine Synthetase Deficiency with Intracranial Hemorrhage Can Mimic Molybdenum Cofactor Deficiency. | Abdel-Salam, GMH. and Abdel-Hamid, MS. 2021. Neuropediatrics. 52: 201-207. PMID: 33271615
- Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma. | Fu, Y., et al. 2021. Front Oncol. 11: 637226. PMID: 33777794
- Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation. | Hope, HC., et al. 2021. JCI Insight. 6: PMID: 33822775
- Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells. | Nishikawa, G., et al. 2022. Cells. 11: PMID: 36291140
- Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells. | Chang, MC., et al. 2023. Nutrients. 15: PMID: 37111157
- Utility of AlphaMissense predictions in Asparagine Synthetase deficiency variant classification. | Staklinski, SJ., et al. 2023. bioRxiv.. PMID: 37961642
- Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer. | Lu, L., et al. 2025. Int J Cancer. 156: 52-68. PMID: 39039782
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Asparagine synthetase Antibody (F-3) | sc-376151 | 200 µg/ml | $322.00 | |||
Asparagine synthetase Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-537974 | 200 µg Ab; 10 µg BP | $361.00 | |||
Asparagine synthetase Antibody (F-3): m-IgGκ BP-HRP Bundle | sc-535470 | 200 µg Ab; 40 µg BP | $361.00 | |||
Asparagine synthetase Antibody (F-3): m-IgG2b BP-HRP Bundle | sc-549906 | 200 µg Ab; 10 µg BP | $361.00 |