alpha-taxilin Antibody (A-6): sc-166648

α-taxilin Antibody (A-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects alpha-taxilin of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-alpha-taxilin antibody (A-6) is available as a non-conjugated format. Alpha-taxilin plays a crucial role in intracellular vesicle trafficking, acting as a novel binding partner of the syntaxin family. Alpha-taxilin′s C-terminal coiled-coil region facilitates interaction with the nascent polypeptide-associated complex (NAC), which is essential for transcriptional coactivation. Notably, alpha-taxilin primarily binds to the α subunit of NAC, and co-expression with overexpressed αNAC disrupts the nuclear distribution of αNAC, which is typically found throughout the cytosol and nucleus. This interaction highlights alpha-taxilin′s importance in regulating the localization and function of NAC, suggesting that the taxilin family, including β- and γ-taxilins, not only influences the translational process through NAC interaction but also plays a significant role in transcriptional regulation via αNAC. Alpha-taxilin′s ability to modulate these processes underscores its potential as a target for research into cellular mechanisms and disease states related to vesicle trafficking and gene expression.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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alpha-taxilin Antibody (A-6) References:

1. Developmental and spatial expression pattern of alpha-taxilin in the rat central nervous system.  |  Sakakibara, S., et al. 2008. J Comp Neurol. 511: 65-80. PMID: 18729150
2. Increased alpha-taxilin protein expression is associated with the metastatic and invasive potential of renal cell cancer.  |  Mashidori, T., et al. 2011. Biomed Res. 32: 103-10. PMID: 21551945
3. Interaction of α-taxilin localized on intracellular components with the microtubule cytoskeleton.  |  Horii, Y., et al. 2012. Cell Struct Funct. 37: 111-26. PMID: 22785156
4. Identification of α-taxilin as an essential factor for the life cycle of hepatitis B virus.  |  Hoffmann, J., et al. 2013. J Hepatol. 59: 934-41. PMID: 23816704
5. Expression of α-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation.  |  Horii, Y., et al. 2014. Histochem Cell Biol. 141: 165-80. PMID: 24091795
6. α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.  |  Sakane, H., et al. 2014. PLoS One. 9: e93509. PMID: 24690921
7. Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.  |  Elgner, F., et al. 2016. Biochem J. 473: 145-55. PMID: 26527738
8. α-taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer.  |  Kanamori, A., et al. 2017. Oncol Lett. 14: 1471-1476. PMID: 28789367
9. High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.  |  Lv, S., et al. 2020. Biomed Res Int. 2020: 2585862. PMID: 32185195
10. TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.  |  Tian, X., et al. 2023. Biochim Biophys Acta Mol Cell Res. 1870: 119550. PMID: 37506885

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α-taxilin Antibody (A-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-α-taxilin Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α-taxilin Antibody (A-6) Specifications

Alternate Product Name: α-taxilin

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 481-554

Epitope Target: α-taxilin

Epitope Species: mouse

Product Reactivity/Detection: α-taxilin

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for α-taxilin Antibody (A-6): N/A

The preferred α-taxilin antibody is α-taxilin Antibody (E-2): sc-271783.