Adducin α Antibody (A-5): sc-133079
- Adducin α Antibody (A-5) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 581-680 of Adducin α of human origin
- recommended for detection of Adducin α of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Adducin α Antibody (A-5) for WB and IHC(P) applications. These reagents are now offered in bundles with Adducin α Antibody (A-5) (see ordering information below).
Adducin α Antibody (A-5) is a mouse monoclonal IgG2a antibody that detects Adducin α in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Adducin α is a crucial cytoskeletal protein that plays a significant role in organizing the cortical actin cytoskeletal network, which maintains cell shape and stability. Adducin α is particularly important in the renal tubule, where Adducin α is involved in sodium-pump activity, linking Adducin α to blood pressure regulation and hypertension pathophysiology. Adducin α expression is ubiquitous, contrasting with the more restricted expression of Adducin β, which is predominantly found in brain and hematopoietic tissues. Adducin α interactions with other cytoskeletal proteins at the spectrin-actin junction highlights Adducin α importance in cellular architecture and signaling pathways, making anti-Adducin α antibody (A-5) an invaluable tool for researchers studying cytoskeletal dynamics and related physiological processes.
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Adducin α Antibody (A-5) References:
- Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. | Abdi, KM. and Bennett, V. 2008. Mol Biol Cell. 19: 536-45. PMID: 18003973
- γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter. | Dimke, H., et al. 2011. J Am Soc Nephrol. 22: 508-17. PMID: 21164023
- Hts/Adducin controls synaptic elaboration and elimination. | Pielage, J., et al. 2011. Neuron. 69: 1114-31. PMID: 21435557
- The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter. | Leite, SC., et al. 2016. Cell Rep. 15: 490-498. PMID: 27068466
- Lipid raft‑associated β‑adducin participates in neutrophil migration. | Yang, C., et al. 2018. Mol Med Rep. 18: 1353-1360. PMID: 29901076
- The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation. | Thauland, TJ., et al. 2019. Front Immunol. 10: 2706. PMID: 31824498
- The Actin-Binding Protein α-Adducin Modulates Desmosomal Turnover and Plasticity. | Hiermaier, M., et al. 2021. J Invest Dermatol. 141: 1219-1229.e11. PMID: 33098828
- Knockout of γ-Adducin Promotes NG-Nitro-L-Arginine-Methyl-Ester-Induced Hypertensive Renal Injury. | Fan, L., et al. 2021. J Pharmacol Exp Ther. 377: 189-198. PMID: 33414130
- Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells. | Suo, Z., et al. 2022. Tumori. 108: 600-608. PMID: 34632867
- Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. | Matsuoka, Y., et al. 1996. J Biol Chem. 271: 25157-66. PMID: 8810272
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adducin α Antibody (A-5) | sc-133079 | 200 µg/ml | $322.00 | |||
Adducin α Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-539844 | 200 µg Ab; 10 µg BP | $361.00 | |||
Adducin α Antibody (A-5): m-IgG2a BP-HRP Bundle | sc-546796 | 200 µg Ab; 10 µg BP | $361.00 |