Date published: 2026-5-4

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5-Hydroxy-L-tryptophan (CAS 4350-09-8)

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Alternate Names:
L-2-Amino-3-(5-hydroxyindolyl)propionic acid
Application:
5-Hydroxy-L-tryptophan is a serotonin precursor
CAS Number:
4350-09-8
Purity:
≥95%
Molecular Weight:
220.22
Molecular Formula:
C11H12N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Hydroxy-L-tryptophan (5-HTP) is an intriguing compound that plays a pivotal role in the biosynthesis of serotonin, a neurotransmitter involved in regulating mood, sleep, and appetite among other physiological processes. Within research applications, 5-Hydroxy-L-tryptophan garners attention for its potential to elucidate the serotonergic system′s functioning and its implications in various neurological pathways. It is synthesized from L-tryptophan, a naturally occurring amino acid, through the action of the enzyme tryptophan hydroxylase. This transformation represents a key step in the metabolic pathway leading to serotonin production. In studies focusing on neurotransmission, 5-Hydroxy-L-tryptophan serves as useful for investigating the synthesis and regulation of serotonin, offering insights into the intricate mechanisms that underlie serotonin′s wide-ranging effects on cellular signaling and neural communication. The use of 5-Hydroxy-L-tryptophan in research models provides a unique window into understanding the complex interplay between neurotransmitter synthesis, release, and reuptake, which is vital for the development of novel approaches to study brain function and neurochemistry.


5-Hydroxy-L-tryptophan (CAS 4350-09-8) References

  1. Systemic 5-hydroxy-L-tryptophan down-regulates the arcuate CART mRNA level in rats.  |  Choi, SH., et al. 2003. Regul Pept. 115: 73-80. PMID: 12972322
  2. Effect of 5-hydroxy-L-tryptophan on the release of 5-HT in rat hypothalamus in vivo as measured by microdialysis.  |  Gartside, SE., et al. 1992. Neuropharmacology. 31: 9-14. PMID: 1531865
  3. Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats.  |  Ma, Z., et al. 2008. Eur J Pharmacol. 588: 198-206. PMID: 18499101
  4. Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum.  |  Kino, K., et al. 2009. J Biosci Bioeng. 108: 184-9. PMID: 19664549
  5. 5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.  |  Larsen, M., et al. 2010. Eur J Pharm Sci. 39: 68-75. PMID: 19900542
  6. Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat.  |  Baumann, MH., et al. 2011. Drug Alcohol Depend. 114: 147-52. PMID: 21071157
  7. 5-hydroxy-L-tryptophan Suppressed Food Intake in Rats Despite an Increase in the Arcuate NPY Expression.  |  Moon, YW., et al. 2010. Exp Neurobiol. 19: 132-9. PMID: 22110352
  8. Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration.  |  Hara, R. and Kino, K. 2013. AMB Express. 3: 70. PMID: 24321061
  9. Natural products of relevance in the prevention and supportive treatment of depression.  |  Muszyńska, B., et al. 2015. Psychiatr Pol. 49: 435-53. PMID: 26276913
  10. Short communication: Supplementation of colostrum and milk with 5-hydroxy-l-tryptophan affects immune factors but not growth performance in newborn calves.  |  Hernández-Castellano, LE., et al. 2018. J Dairy Sci. 101: 794-800. PMID: 29102139
  11. Interaction of 5-hydroxy-l-tryptophan and negative dietary cation-anion difference on calcium homeostasis in multiparous peripartum dairy cows.  |  Slater, CJ., et al. 2018. J Dairy Sci. 101: 5486-5501. PMID: 29605319
  12. 5-Hydroxy-l-tryptophan Promotes the Milk Calcium Level via the miR-99a-3p/ATP2B1 Axis in Goat Mammary Epithelial Cells.  |  Chen, S., et al. 2020. J Agric Food Chem. 68: 3277-3285. PMID: 32054265
  13. Short communication: The effect of ruminal administration of 5-hydroxy-l-tryptophan on circulating serotonin concentrations.  |  Connelly, MK., et al. 2020. J Dairy Sci. 103: 10850-10855. PMID: 32952021
  14. In vitro effects of 5-Hydroxy-L-tryptophan supplementation on primary bovine mammary epithelial cell gene expression under thermoneutral or heat shock conditions.  |  Field, SL., et al. 2022. Sci Rep. 12: 3820. PMID: 35264606
  15. Neuroendocrine response to 5-hydroxy-L-tryptophan in prepubertal children at high risk of major depressive disorder.  |  Birmaher, B., et al. 1997. Arch Gen Psychiatry. 54: 1113-9. PMID: 9400347

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Hydroxy-L-tryptophan, 5 g

sc-278210
5 g
$120.00

5-Hydroxy-L-tryptophan, 25 g

sc-278210A
25 g
$388.00