4.1N Antibody (H-1): sc-514534
- 4.1N Antibody (H-1) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 425-451 within an internal region of 4.1N of human origin
- recommended for detection of 4.1N of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for 4.1N Antibody (H-1) for WB applications. These reagents are now offered in bundles with 4.1N Antibody (H-1) (see ordering information below).
4.1N Antibody (H-1) is a mouse monoclonal IgG1 antibody that detects 4.1N in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4.1N, also known as band 4.1-like protein 1 or neuronal protein 4.1, plays a crucial role in binding and stabilizing D2 and D3 dopamine receptors at the neuronal plasma membrane, which is essential for maintaining proper neurotransmission and neuronal signaling. 4.1N is predominantly expressed in the brain, with lower levels found in the heart, kidney, pancreas, placenta, lung, and skeletal muscle, highlighting its significance in the central nervous system. 4.1N interacts with the cytoskeleton and the plasma membrane, contributing to the stability and plasticity of neuronal membranes, which is vital for synaptic function and adaptability. Additionally, the 4.1 family consists of four homologous genes—4.1R, 4.1G, 4.1N, and 4.1B—that undergo complex alternative splicing, suggesting a diverse range of functions and regulatory mechanisms. The specific distribution of these spliced gene products along the nephron indicates their potential involvement in the targeting of selected transmembrane proteins in kidney epithelium, thereby influencing the regulation of various kidney functions. Anti-4.1N antibody (H-1) serves as an invaluable tool for researchers studying the intricate dynamics of neuronal signaling and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4.1N Antibody (H-1) | sc-514534 | 200 µg/ml | $322.00 | |||
4.1N Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-538658 | 200 µg Ab; 10 µg BP | $361.00 | |||
4.1N Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-536312 | 200 µg Ab; 40 µg BP | $361.00 | |||
4.1N Antibody (H-1): m-IgG1 BP-HRP Bundle | sc-545817 | 200 µg Ab; 20 µg BP | $361.00 | |||
4.1N (H-1) Neutralizing Peptide | sc-514534 P | 100 µg/0.5 ml | $69.00 |