4.1N Antibody (4): sc-135817
- 4.1N Antibody (4) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 510-626 of 4.1N of mouse origin
- recommended for detection of 4.1N of mouse, rat, human and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for 4.1N Antibody (4). This work is in progress.
4.1N Antibody (4) is a mouse monoclonal IgG1 antibody that recognizes 4.1N in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. 4.1N, also known as band 4.1-like protein 1 or neuronal protein 4.1, plays a crucial role in binding and stabilizing D2 and D3 dopamine receptors at the neuronal plasma membrane, which is essential for maintaining proper neurotransmission and neuronal signaling. Anti-4.1N antibody (4) helps study protein interactions with the cytoskeleton and plasma membrane, which are vital for conferring stability and plasticity to neuronal membranes, thereby influencing synaptic function and plasticity. 4.1N is predominantly expressed in the brain, with lower expression levels found in the heart, kidney, pancreas, placenta, lung, and skeletal muscle, highlighting its significance in neural tissues. The complexity of the 4.1 family is further underscored by the presence of four homologous genes (4.1R, 4.1G, 4.1N, and 4.1B), which undergo intricate alternative splicing. This splicing diversity suggests that the various 4.1 protein isoforms may have specialized roles, particularly in the targeting of transmembrane proteins within kidney epithelium, thus contributing to the regulation of specific kidney functions. 4.1N monoclonal antibody (4) is an invaluable tool for researchers investigating the dynamics of neuronal signaling and the functional implications of 4.1N in various physiological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4.1N Antibody (4) | sc-135817 | 50 µg/0.5 ml | $322.00 |