15-LO2 Antibody (D-6): sc-376871

15-LO2 Antibody (D-6) is a mouse monoclonal IgG1 antibody that detects 15-lipoxygenase type II (15-LO2) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 15-LO2 plays a crucial role in the metabolism of arachidonic acid, converting it into 15S-hydroperoxyeicosatetraenoic acid, which is a key intermediate in the biosynthesis of various bioactive lipids. This enzymatic activity influences numerous physiological processes, including inflammation, cell signaling, and tissue remodeling. Proper functioning of 15-LO2 is essential for maintaining cellular homeostasis and responding to stress signals, and dysregulation has been linked to various pathological conditions, including cancer and cardiovascular diseases. Expression of 15-LO2 is primarily localized in the cytoplasm and is notably found in tissues such as the cornea, lung, hair follicles, and prostate, highlighting importance in both normal physiology and disease states. Regulation of 15-LO2 is complex and involves various signaling pathways, including those mediated by cytokines like IL-4 and IL-13, which can enhance expression and activity, further underscoring relevance in health and disease.

The preferred 15-LO2 antibody is 15-LO2 Antibody (F-10): sc-376795.