MITF Inhibitoren
TIF1α inhibitors belong to a specific chemical class known for their ability to modulate the activity of the Transcriptional Intermediary Factor 1 alpha (TIF1α) protein. TIF1α, also known as TRIM24, is a transcriptional co-regulator that plays a crucial role in various cellular processes, including gene expression regulation, DNA repair, and cellular differentiation. These inhibitors are designed to specifically target TIF1α, thereby disrupting its normal function.
The mechanism of action of TIF1α inhibitors involves binding to the active site or other key regions of the TIF1α protein, leading to conformational changes that inhibit its normal interactions with other cellular factors and proteins. By doing so, these inhibitors can interfere with the recruitment of TIF1α to gene promoters, alter chromatin remodeling processes, and subsequently influence gene expression patterns within the cell. Researchers and scientists have been exploring TIF1α inhibitors as valuable tools for understanding the molecular mechanisms governing gene regulation and chromatin remodeling processes. By modulating TIF1α activity, these inhibitors can offer valuable insights into the intricate regulatory networks controlling cellular functions, including development and differentiation. Studying the effects of TIF1α inhibitors in various experimental settings can aid in unraveling the complex interplay between different cellular factors.
| Produkt | CAS # | Katalog # | Menge | Preis | Referenzen | Bewertung |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Aza-2'-Desoxycytidin ist ein DNA-Methyltransferase-Inhibitor, der indirekt die MITF-Expression beeinflusst. Er hemmt DNA-Methyltransferasen, was zu einer DNA-Hypomethylierung am MITF-Promotor führt, was wiederum zu einer erhöhten MITF-Expression und Melanogenese führt. | ||||||
GW8510 | 222036-17-1 | sc-215122 sc-215122A | 1 mg 5 mg | $287.00 $614.00 | 8 | |
GW-8510 ist ein Proteinkinase-Inhibitor, der indirekt die MITF-Phosphorylierung hemmen kann. Er blockiert die Aktivität von Kinasen, die für die MITF-Phosphorylierung verantwortlich sind, wodurch die MITF-Transkriptionsaktivität reduziert und die Melanozytendifferenzierung und Melaninsynthese beeinflusst werden. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $78.00 $233.00 $809.00 | 5 | |
Pyrimethamin, ein Antimalariamittel, kann die MITF-Expression indirekt hemmen. Es greift in Histonacetyltransferasen (HATs) ein, was zu einer Histonhypoacetylierung am MITF-Promotor und einer verringerten MITF-Expression führt, wodurch die Melanogenese gehemmt wird. | ||||||
SB 590885 | 405554-55-4 | sc-363287 sc-363287A | 10 mg 50 mg | $219.00 $924.00 | ||
SB-590885 ist ein potenter und selektiver Inhibitor der MITF-Aktivität. Er zielt auf die MITF-DNA-Bindungsdomäne ab und unterbricht deren Interaktion mit den Promotoren der Zielgene, was zur Herunterregulierung von Genen führt, die an der Melanozytendifferenzierung und Melanogenese beteiligt sind. | ||||||