AKR1A1 Activators
ldo-keto reductase family 1 member A1 (AKR1A1) is a protein that in humans is encoded by the AKR1A1 gene. This protein is part of the aldo-keto reductase (AKR) superfamily and is involved in the breakdown and detoxification of aldehydes and ketones, and the metabolism of hormones and xenobiotics.AKR1A1 catalyzes the reduction of aldehydes and ketones to their corresponding alcohols, a critical step in detoxifying these substances, which can be harmful to the cell. It also plays a role in the metabolism of glucose via the polyol pathway, converting glucose to sorbitol, which can then be metabolized further.
Additionally, AKR1A1 participates in the inactivation and activation of a variety of steroid hormones, including glucocorticoids, mineralocorticoids, and sex steroids. In this way, it can influence numerous biological processes that are regulated by these hormones.The dysregulation of AKR1A1 has been associated with different pathologies, including diabetes complications and various types of cancer. For instance, in the context of diabetes, the excessive conversion of glucose to sorbitol by AKR1A1 can lead to osmotic stress, contributing to diabetic complications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Vitamin E is another antioxidant that might indirectly affect the redox-sensitive processes involving AKR1A1. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
High glucose levels can increase the substrate availability for AKR1A1, potentially upregulating its activity in certain contexts. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
As a major cellular antioxidant, glutathione might interact with redox-sensitive pathways involving AKR1A1. | ||||||
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $80.00 $351.00 $621.00 $12791.00 | 5 | |
Beta-carotene, with its antioxidant properties, might influence the redox environment and indirectly affect AKR1A1. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Lipoic acid, known for its role in oxidative stress, could modulate the cellular redox state, potentially impacting AKR1A1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, with its antioxidant and anti-inflammatory properties, might influence the redox balance affecting AKR1A1. | ||||||