Date published: 2026-2-26

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Urolithin B (CAS 1139-83-9)

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Alternate Names:
3-Hydroxy-6H-dibenzo[b,d]pyran-6-one
CAS Number:
1139-83-9
Purity:
≥98%
Molecular Weight:
212.20
Molecular Formula:
C13H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Urolithin B is a metabolite compound that is the focus of research in the field of biochemistry, particularly concerning its role as a product of the microbial metabolism of ellagitannins and ellagic acid found in various fruits and nuts. Due to its potential influence on cellular functions, it is of interest in studies on cell signaling pathways and gene expression. In addition, Urolithin B is studied for its impact on mitochondrial function, where researchers explore its effects on mitochondrial biogenesis and dynamics. The compound is also used in the field of food science to understand the transformation of dietary polyphenolics during digestion and absorption. Furthermore, researchers investigate the compound′s interactions with proteins and enzymes, which may shed light on its potential mechanisms of action within biological systems.


Urolithin B (CAS 1139-83-9) References

  1. Urolithin B, a newly identified regulator of skeletal muscle mass.  |  Rodriguez, J., et al. 2017. J Cachexia Sarcopenia Muscle. 8: 583-597. PMID: 28251839
  2. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia.  |  Lee, G., et al. 2019. Phytomedicine. 55: 50-57. PMID: 30668443
  3. Urolithin A and B Derivatives as ON-OFF Selective Fluorescent Sensors for Iron(III).  |  Fallah, A., et al. 2020. J Fluoresc. 30: 113-120. PMID: 31897913
  4. Urolithin B improves cardiac function and reduces susceptibility to ventricular arrhythmias in rats after myocardial infarction.  |  Gao, H., et al. 2020. Eur J Pharmacol. 871: 172936. PMID: 31958459
  5. Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway.  |  Hassanein, EHM., et al. 2020. Oxid Med Cell Longev. 2020: 1675957. PMID: 32377290
  6. Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme.  |  Singh, R., et al. 2020. Metabolites. 10: PMID: 32575435
  7. Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells.  |  Alzahrani, AM., et al. 2021. Int J Mol Sci. 22: PMID: 34067305
  8. Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signalling.  |  Chen, P., et al. 2021. Food Funct. 12: 11938-11955. PMID: 34747418
  9. Correction: Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signalling.  |  Chen, P., et al. 2022. Food Funct. 13: 2372-2373. PMID: 35088799
  10. Urolithin B, a Gut Microbiota Metabolite, Reduced Susceptibility to Myocardial Arrhythmic Predisposition after Hypoxia.  |  Huang, X., et al. 2022. Dis Markers. 2022: 6517266. PMID: 35178131
  11. Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF-κB pathway.  |  Li, Y., et al. 2022. Cell Prolif. 55: e13291. PMID: 35708050
  12. Urolithin B suppresses osteoclastogenesis via inhibiting RANKL-induced signalling pathways and attenuating ROS activities.  |  Qu, Z., et al. 2022. J Cell Mol Med. 26: 4428-4439. PMID: 35781786
  13. Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From Ellagitannins.  |  Chen, P., et al. 2022. Front Pharmacol. 13: 917266. PMID: 35814202
  14. Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes.  |  Raimundo, AF., et al. 2022. Front Endocrinol (Lausanne). 13: 1008418. PMID: 36589826

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Urolithin B, 1 g

sc-475547
1 g
$320.00

Urolithin B, 10 g

sc-475547A
10 g
$2200.00