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4-tert-Butylphenyl Salicylate (CAS 87-18-3)

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Alternate Names:
Salicylic Acid 4-tert-Butylphenyl Ester
CAS Number:
87-18-3
Molecular Weight:
270.33
Molecular Formula:
C17H18O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-tert-Butylphenyl salicylate (4-TBS) belongs to the phenylsalicylate family of compounds, specifically as a phenyl salicylate derivative. It presents as a white crystalline solid. This compound exhibits solubility in organic solvents like ethanol, acetone, and ethyl acetate, while remaining insoluble in water. The applications of 4-TBS extend to various research and laboratory contexts. It serves as a reagent for the synthesis of organic compounds, a chromatographic stationary phase, and a substrate for enzyme assays. 4-tert-Butylphenyl salicylate functions as an electron-rich phenol, enabling reactions with other molecules to yield a range of products. These reactions are typically catalyzed by various acids, such as sulfuric acid, and the resulting products are contingent upon the specific reaction conditions. For instance, in the presence of sulfuric acid, 4-tert-Butylphenyl salicylate can undergo reactions with other molecules, leading to the formation of esters, ethers, and other related products.


4-tert-Butylphenyl Salicylate (CAS 87-18-3) References

  1. Use of trout liver slices to enhance mechanistic interpretation of estrogen receptor binding for cost-effective prioritization of chemicals within large inventories.  |  Schmieder, PK., et al. 2004. Environ Sci Technol. 38: 6333-42. PMID: 15597890
  2. Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses.  |  Rotroff, DM., et al. 2014. Environ Sci Technol. 48: 8706-16. PMID: 24960280
  3. [Kinetic migration of 4-cumylphenol and 4-tert-butylphenyl salicylate from paper packaging to dry food simulant Tenax TA].  |  Han, W., et al. 2014. Se Pu. 32: 1349-55. PMID: 25902642
  4. Anti-inflammatory function of 4-tert-butylphenyl salicylate through down-regulation of the NF-kappa B pathway.  |  Choi, YH., et al. 2016. Arch Pharm Res. 39: 429-36. PMID: 26849878

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-tert-Butylphenyl Salicylate, 25 g

sc-474338
25 g
$42.00