Molecular structure of Ajmalicine
Ajmalicine (CAS 483-04-5)
Alternate Names:
δ-Yohimbine
CAS Number:
483-04-5
Molecular Weight:
352.43
Molecular Formula:
C21H24N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ajmalicine, also referred to as raubasine, is a monoterpene indole alkaloid sourced from the root of Rauwolfia serpentina. Ajmalicine has undergone extensive investigation. In vitro studies employ cell cultures or tissue samples to observe the effects of ajmalicine on cells or tissues. Although the precise mechanism of action of ajmalicine remains incompletely understood, it is believed to interact with various targets, including voltage-gated calcium channels, serotonin receptors, and GABA receptors.
Ajmalicine (CAS 483-04-5) References
- Influence of fungal elicitors on production of ajmalicine by cell cultures of Catharanthus roseus. | Namdeo, A., et al. 2002. Biotechnol Prog. 18: 159-62. PMID: 11822914
- The effect of ajmalicine spiking and resin addition timing on the production of indole alkaloids from Catharanthus roseus cell cultures. | Lee-Parsons, CW. and Shuler, ML. 2002. Biotechnol Bioeng. 79: 408-15. PMID: 12115404
- Studies on production of ajmalicine in shake flasks by multiple shoot cultures of Catharanthus roseus. | Satdive, RK., et al. 2003. Biotechnol Prog. 19: 1071-5. PMID: 12790683
- Ajmalicine production in methyl jasmonate-induced Catharanthus roseus cell cultures depends on Ca2+ level. | Lee-Parsons, CW. and Ertürk, S. 2005. Plant Cell Rep. 24: 677-82. PMID: 16094527
- Ajmalicine, Serpentine, and Catharanthine Accumulation in Catharanthus roseus Bioreactor Cultures. | Drapeau, D., et al. 1987. Planta Med. 53: 373-6. PMID: 17269046
- The role of glucose in ajmalicine production by catharanthus roseus cell cultures. | Schlatmann, JE., et al. 1995. Biotechnol Bioeng. 47: 525-34. PMID: 18623431
- Tryptophan decarboxylase plays an important role in ajmalicine biosynthesis in Rauvolfia verticillata. | Liu, W., et al. 2012. Planta. 236: 239-50. PMID: 22331368
- Uptake and accumulation of ajmalicine into isolated vacuoles of cultured cells of Catharanthus roseus (L.) G. Don. and its conversion into serpentine. | Blom, TJ., et al. 1991. Planta. 183: 170-7. PMID: 24193617
- Endophytes enhance the production of root alkaloids ajmalicine and serpentine by modulating the terpenoid indole alkaloid pathway in Catharanthus roseus roots. | Singh, S., et al. 2020. J Appl Microbiol. 128: 1128-1142. PMID: 31821696
- Conversion of Cytochrome P450 2D6 of Human Into a FRET-Based Tool for Real-Time Monitoring of Ajmalicine in Living Cells. | Ambrin, G., et al. 2019. Front Bioeng Biotechnol. 7: 375. PMID: 31828069
- Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer's Disease. | Kashyap, P., et al. 2020. Molecules. 25: PMID: 32244635
- Ajmalicine and its Analogues Against AChE and BuChE for the Management of Alzheimer's Disease: An In-silico Study. | Liu, S., et al. 2020. Curr Pharm Des. 26: 4808-4814. PMID: 32264807
- Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast. | Liu, T., et al. 2022. Biotechnol Bioeng. 119: 1314-1326. PMID: 35060115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ajmalicine, 10 mg | sc-396582 | 10 mg | $60.00 | |||
Ajmalicine, 50 mg | sc-396582A | 50 mg | $232.00 |