Molecular structure of Zerumbone, CAS Number: 471-05-6
Zerumbone (CAS 471-05-6)
Alternate Names:
(2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one
CAS Number:
471-05-6
Molecular Weight:
218.3
Molecular Formula:
C15H22O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Zerumbone, an unstable sesquiterpene, is present in the essential oil found in Zingiber zerumbet, a tropical plant indigenous to Southeast Asia. Zerumbone functions by hindering the production of pro-inflammatory cytokines and enzymes, as well as regulating the activity of specific enzymes involved in the inflammatory response. Its applications in scientific studies are broad, ranging from examining its impact on molecular pathways to understanding its interactions within biological systems.
Zerumbone (CAS 471-05-6) References
- Exploring the immunomodulatory and anticancer properties of zerumbone. | Haque, MA., et al. 2017. Food Funct. 8: 3410-3431. PMID: 28714500
- Potential of Zerumbone as an Anti-Cancer Agent. | Girisa, S., et al. 2019. Molecules. 24: PMID: 30781671
- Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling. | Li, L., et al. 2020. J Neuroinflammation. 17: 61. PMID: 32066466
- Zerumbone Restores Gut Microbiota Composition in ETBF Colonized AOM/DSS Mice. | Cho, HW., et al. 2020. J Microbiol Biotechnol. 30: 1640-1650. PMID: 32958727
- Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone. | Kesharwani, SS. and Bhat, GJ. 2020. Medicina (Kaunas). 56: PMID: 33114101
- Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages. | Su, CC., et al. 2021. Front Pharmacol. 12: 652860. PMID: 34045963
- Zerumbone Inhibits Helicobacter pylori Urease Activity. | Woo, HJ., et al. 2021. Molecules. 26: PMID: 34062878
- Zerumbone acts as a radiosensitizer in head and neck squamous cell carcinoma. | Schnoell, J., et al. 2022. Invest New Drugs. 40: 224-231. PMID: 34613571
- Transition Metal/Lewis Acid Catalyzed Reactions of Zerumbone for Diverse Molecular Motifs. | Biji, M., et al. 2021. Chem Rec. 21: 3943-3953. PMID: 34708494
- Evaluation of anti-methicillin-resistant Staphylococcus aureus property of zerumbone. | Fadhel Abbas Albaayit, S., et al. 2022. J Appl Biomed.. PMID: 35170271
- Zerumbone suppresses high glucose and LPS-induced inflammation in THP-1-derived macrophages by inhibiting the NF-κB/TLR signaling pathway. | Kim, A., et al. 2022. Nutr Res. 100: 58-69. PMID: 35220082
- Tumor-Inhibitory Effects of Zerumbone Against HT-29 Human Colorectal Cancer Cells. | Memari, F., et al. 2022. Int J Toxicol. 41: 402-411. PMID: 35719111
- Anticancer bioactivity of zerumbone on pediatric rhabdomyosarcoma cells. | Urla, C., et al. 2022. J Cancer Res Clin Oncol.. PMID: 35931788
- Zerumbone-Loaded Nanostructured Lipid Carrier Gel Enhances Wound Healing in Diabetic Rats. | Albaayit, SFA., et al. 2022. Biomed Res Int. 2022: 1129297. PMID: 36124067
- Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration. | Ibáñez, MD., et al. 2022. Plants (Basel). 12: PMID: 36616138
Inhibitor of:
βA4-crystallin, AHSA2, Bag-5, C20orf96, CCDC141, ESAT6, HSF2, HSPB3, HSPBAP1, HSPC159, MGST1, and UBA52.Activator of:
AKR1E1, ALDH3A1, BC015286, Gsta1, GSTM4, GSTO2, GSTT4, HSF4, HSFY2, HSP 40-4, HSPA1L, Ly-55B, PTP22, SH3BGRL, UGT1A10, UGT1A9, UGT2B37, UNCL, and Ydj1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zerumbone, 10 mg | sc-364148 | 10 mg | $110.00 | |||
Zerumbone, 50 mg | sc-364148A | 50 mg | $400.00 |