Hypericin (CAS 548-04-9)
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Hypericin is a polycyclic quinone found in St. John′s wort (Hypericum perforatum). In research, hypericin is known for its strong photodynamic activity, meaning it produces a biological effect when exposed to light, particularly in the visible spectrum. This property is harnessed in studies exploring photodynamic therapy, wherein hypericin is investigated for its ability to generate reactive oxygen species upon illumination. These reactive species can cause cellular damage, which is of interest in the selective targeting of cells in various experimental models. Additionally, its role in the light-dependent inhibition of certain viral and retroviral enzymes makes hypericin a valuable compound in virology research. It is also used to study its potential impact on signal transduction pathways related to light perception and response in biological systems.
Hypericin (CAS 548-04-9) References
- Photoactivated hypericin induces downregulation of HER2 gene expression. | Solár, P., et al. 2011. Radiat Res. 175: 51-6. PMID: 21175347
- Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. | Takahashi, I., et al. 1989. Biochem Biophys Res Commun. 165: 1207-12. PMID: 2558652
- Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. | Meruelo, D., et al. 1988. Proc Natl Acad Sci U S A. 85: 5230-4. PMID: 2839837
- Hypericin inclusion complexes encapsulated in liposomes for antimicrobial photodynamic therapy. | Plenagl, N., et al. 2019. Int J Pharm. 570: 118666. PMID: 31494239
- Hypericin: Single Molecule Spectroscopy of an Active Natural Drug. | Liu, Q., et al. 2020. J Phys Chem A. 124: 2497-2504. PMID: 32126168
- Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells. | de Souza, LM., et al. 2022. Drug Chem Toxicol. 45: 1302-1307. PMID: 33050761
- Hypericin induces apoptosis in K562 cells via downregulation of Myc and Mdm2. | Arani, HZ., et al. 2021. J Cancer Res Ther. 17: 242-247. PMID: 33723162
- Hypericin in photobiological assays: An overview. | de Andrade, GP., et al. 2021. Photodiagnosis Photodyn Ther. 35: 102343. PMID: 34038765
- Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease. | Zhang, Y., et al. 2021. Viruses. 13: PMID: 34578406
- Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination. | Wang, D., et al. 2022. Curr Drug Metab. 23: 38-44. PMID: 35114918
- The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity. | Delcanale, P., et al. 2022. ACS Appl Mater Interfaces. 14: 14025-14032. PMID: 35302731
- Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication. | Cao, K., et al. 2022. J Ethnopharmacol. 296: 115524. PMID: 35811028
- Spectroscopy studies of interaction hypericin with an anti-cancer therapy drug doxorubicin. | Pietrzak, M., et al. 2022. Biophys Chem. 288: 106858. PMID: 35905651
- On the origin of photodynamic activity of hypericin and its iodine-containing derivatives. | De Simone, BC., et al. 2022. J Comput Chem. 43: 2037-2042. PMID: 36129210
- Hypericin in phototherapy. | Koren, H., et al. 1996. J Photochem Photobiol B. 36: 113-9. PMID: 9002247
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hypericin, 1 mg | sc-3530 | 1 mg | $66.00 | |||
Hypericin, 5 mg | sc-3530A | 5 mg | $214.00 |