Molecular structure of 5-Methoxyflavone, CAS Number: 42079-78-7
5-Methoxyflavone (CAS 42079-78-7)
CAS Number:
42079-78-7
Purity:
97%
Molecular Weight:
252.26
Molecular Formula:
C16H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Methoxyflavone (5-MF) is a flavone compound that possesses lipophilic properties, allowing it to dissolve in lipids and fatty acids. While the exact mechanism of action of 5-Methoxyflavone remains partially understood, several pathways have been proposed. Additionally, it has been observed to inhibit the activity of cyclooxygenase-2, an enzyme responsible for the production of pro-inflammatory prostaglandins. Moreover, 5-Methoxyflavone has been found to impede the activity of 5-lipoxygenase, an enzyme involved in the production of leukotrienesan inflammatory mediator.
5-Methoxyflavone (CAS 42079-78-7) References
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- Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity. | Merlo, S., et al. 2015. J Nat Prod. 78: 2704-11. PMID: 26517378
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- Suppressive effects of Vochysia divergens aqueous leaf extract and its 5-methoxyflavone on murine macrophages and lymphocytes. | Corrêa, MFP., et al. 2018. J Ethnopharmacol. 221: 77-85. PMID: 29626672
- Sedative-hypnotic like effect of 5-methoxyflavone in mice and investigation on possible mechanisms by in vivo and in silico methods. | Shanmugasundaram, J., et al. 2018. Biomed Pharmacother. 108: 85-94. PMID: 30218862
- Anxiolytic-like activity of 5-methoxyflavone in mice with involvement of GABAergic and serotonergic systems - in vivo and in silico evidences. | Shanmugasundaram, J., et al. 2020. Eur Neuropsychopharmacol. 36: 100-110. PMID: 32534819
- 5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo. | Yang, S., et al. 2022. Cell Mol Biol Lett. 27: 82. PMID: 36180831
- 5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages. | Liang, P., et al. 2022. J Inflamm (Lond). 19: 24. PMID: 36451220
- 5-Methoxyflavone ameliorates non-alcoholic fatty liver disease through targeting the cytochrome P450 1A1. | Zhang, Y., et al. 2023. Free Radic Biol Med. 195: 178-191. PMID: 36587922
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Methoxyflavone, 100 mg | sc-352702 | 100 mg | $72.00 | |||
5-Methoxyflavone, 500 mg | sc-352702A | 500 mg | $218.00 |