L-(+)-Norleucine (CAS 327-57-1)
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L-(+)-Norleucine is a non-proteinogenic amino acid that functions as a structural analog of leucine. It can be used to investigate the effects of amino acid substitutions on protein structure and function. L-(+)-Norleucine can be incorporated into peptides and proteins during chemical synthesis to study the impact of altered amino acid composition on biological activity. Its mechanism of action involves interacting with the cellular machinery responsible for protein synthesis, potentially influencing the folding, stability, and activity of the resulting molecules. Its presence in experimental systems allows for the investigation of the effects of amino acid modifications on the behavior and properties of proteins, contributing to the understanding of structure-function relationships in biological molecules.
L-(+)-Norleucine (CAS 327-57-1) References
- Ternary Complexes of cis-(NH(3))(2)PtCl(2) (cis-DDP) With Guanosine (guo), Cytidine (cyd) and the Aminoacids Glycine (gly), L-Alanine (ala), L-2-Aminobutyric Acid (2-aba), L-Norvaline (nval) and L-Norleucine (nleu). | Katsarou, E., et al. 1997. Met Based Drugs. 4: 57-63. PMID: 18475769
- L-leucine 5-hydroxylase of Nostoc punctiforme is a novel type of Fe(II)/α-ketoglutarate-dependent dioxygenase that is useful as a biocatalyst. | Hibi, M., et al. 2013. Appl Microbiol Biotechnol. 97: 2467-72. PMID: 22584432
- Lysine degradation in Candida. Characterization and probable role of L-norleucine-leucine, 4-aminobutyrate and delta-aminovalerate:2-oxoglutarate aminotransferases. | Der Garabedian, PA. and Vermeersch, JJ. 1989. Biochimie. 71: 497-503. PMID: 2503054
- Crystal structure of mutant form Cys115His of Citrobacter freundii methionine γ-lyase complexed with l-norleucine. | Revtovich, SV., et al. 2017. Biochim Biophys Acta Proteins Proteom. 1865: 1123-1128. PMID: 28602917
- Enantioselective biocatalytic formal α-amination of hexanoic acid to l-norleucine. | Dennig, A., et al. 2018. Org Biomol Chem. 16: 8030-8033. PMID: 30334043
- Identification of incommensurability in L-leucine: can lattice instabilities be considered as general phenomena in hydrophobic amino acids? | Guinet, Y., et al. 2022. Phys Chem Chem Phys. 24: 27023-27030. PMID: 35946565
- Candida L-norleucine,leucine:2-oxoglutarate aminotransferase. Purification and properties. | Der Garabedian, PA. and Vermeersch, JJ. 1987. Eur J Biochem. 167: 141-7. PMID: 3622507
- On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. | Schott, KJ., et al. 1985. Z Naturforsch C Biosci. 40: 427-37. PMID: 3895764
- 1H NMR studies of substrate hydrogen exchange reactions catalyzed by L-methionine gamma-lyase. | Esaki, N., et al. 1985. Biochemistry. 24: 3857-62. PMID: 4052371
- Does leucine- and norleucine-induced insulin release depend on amino acid aminotransferase activity? | Sener, A., et al. 1983. J Biol Chem. 258: 6693-4. PMID: 6343380
- Inhibition by L-valine and L-norleucine of 3-phenylpyruvate-induced insulin release. | Sener, A. and Malaisse, WJ. 1984. Biochimie. 66: 353-60. PMID: 6380597
- [3H]gabapentin may label a system-L-like neutral amino acid carrier in brain. | Thurlow, RJ., et al. 1993. Eur J Pharmacol. 247: 341-5. PMID: 8307106
- Conformational properties of L-leucine, L-isoleucine, and L-norleucine side chains in L-lysine copolymers. | Arfmann, HA., et al. 1977. Biopolymers. 16: 1815-26. PMID: 890071
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-(+)-Norleucine, 100 mg | sc-300860 | 100 mg | $20.00 |