Date published: 2025-10-14

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Poly-L-Glutamic Acid (CAS 25513-46-6)

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CAS Number:
25513-46-6
Purity:
≥92%
Molecular Weight:
15,000-50,000
Molecular Formula:
(C5H8NO3)n
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Poly-L-glutamic acid is a biopolymer consisting of L-glutamic acid units. Poly-L-glutamic acid has the ability to form stable water-soluble complexes with metal ions. Poly-L-glutamic acid is utilized in the creation of biodegradable materials, serving as an environmentally friendly alternative to synthetic polymers. Its application extends to the development of hydrogels, which are networks of polymer chains that can retain a large amount of water. These hydrogels are explored for their potential in agriculture for water retention in soil, in water purification systems to capture and remove contaminants, and in the packaging industry to create materials that degrade more readily in the environment. Additionally, poly-L-glutamic acid′s ability to form complexes with metals makes it useful in the field of biochemistry for studying metal ion transport and storage. It can also be employed in the synthesis of nanocomposites and nanoparticles.


Poly-L-Glutamic Acid (CAS 25513-46-6) References

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  2. Conjugation of camptothecins to poly-(L-glutamic acid).  |  Singer, JW., et al. 2000. Ann N Y Acad Sci. 922: 136-50. PMID: 11193889
  3. Poly(L-glutamic acid)--anticancer drug conjugates.  |  Li, C. 2002. Adv Drug Deliv Rev. 54: 695-713. PMID: 12204599
  4. Direct observation of the multistep helix formation of poly-L-glutamic acids.  |  Kimura, T., et al. 2002. J Am Chem Soc. 124: 11596-7. PMID: 12296715
  5. Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses.  |  Totani, K., et al. 2003. Glycobiology. 13: 315-26. PMID: 12626382
  6. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier.  |  Tansey, W., et al. 2004. J Control Release. 94: 39-51. PMID: 14684270
  7. UV resonance Raman determination of polyproline II, extended 2.5(1)-helix, and beta-sheet Psi angle energy landscape in poly-L-lysine and poly-L-glutamic acid.  |  Mikhonin, AV., et al. 2005. J Am Chem Soc. 127: 7712-20. PMID: 15913361
  8. The anti-tumor efficiency of poly(L-glutamic acid) dendrimers with polyhedral oligomeric silsesquioxane cores.  |  Pu, Y., et al. 2013. Biomaterials. 34: 3658-66. PMID: 23433775
  9. Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers.  |  Baumgartner, R., et al. 2017. Biomater Sci. 5: 1836-1844. PMID: 28664205
  10. A Lysoganglioside/Poly-L-glutamic Acid Conjugate as a Picomolar Inhibitor of Influenza Hemagglutinin.  |  Kamitakahara, H., et al. 1998. Angew Chem Int Ed Engl. 37: 1524-1528. PMID: 29710929
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  12. Rapidly curable biological glue composed of gelatin and poly(L-glutamic acid).  |  Otani, Y., et al. 1996. Biomaterials. 17: 1387-91. PMID: 8830964
  13. Hemostatic capability of rapidly curable glues from gelatin, poly(L-glutamic acid), and carbodiimide.  |  Otani, Y., et al. 1998. Biomaterials. 19: 2091-8. PMID: 9870761

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Poly-L-Glutamic Acid, 25 mg

sc-296110
25 mg
$153.00

Poly-L-Glutamic Acid, 100 mg

sc-296110A
100 mg
$510.00