Molecular structure of Harmol Hydrochloride, CAS Number: 40580-83-4
Harmol Hydrochloride (CAS 40580-83-4)
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Alternate Names:
1-Methyl-9H-β-carbolin-7-ol hydrochloride
Application:
Harmol Hydrochloride is an apoptosis inducer
CAS Number:
40580-83-4
Molecular Weight:
234.7
Molecular Formula:
C12H10N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Harmol hydrochloride, a synthetic compound, has captivated the attention of researchers in recent decades, instigating extensive investigations into its various properties. The mechanism of action underlying Harmol hydrochloride involves its role as an agonist of particular G-protein coupled receptors, which actively participate in a wide array of cellular processes. Studies have demonstrated its ability to inhibit the activity of specific enzymes, such as acetylcholinesterase, and to modulate gene expression.
Harmol Hydrochloride (CAS 40580-83-4) References
- Non-competitive androgen receptor inhibition in vitro and in vivo. | Jones, JO., et al. 2009. Proc Natl Acad Sci U S A. 106: 7233-8. PMID: 19363158
- Hormonal therapy for prostate cancer: toward further unraveling of androgen receptor function. | Sharifi, N. 2009. Anticancer Agents Med Chem. 9: 1046-51. PMID: 19719456
- Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs). | Moore, TW., et al. 2010. Mol Endocrinol. 24: 683-95. PMID: 19933380
- Small molecule inhibitors as probes for estrogen and androgen receptor action. | Shapiro, DJ., et al. 2011. J Biol Chem. 286: 4043-8. PMID: 21149443
- Mercury-induced UDP-glucuronyltransferase (UDPGT) activity in mouse kidney. | Tan, TM., et al. 1990. Toxicology. 64: 81-7. PMID: 2120797
- Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen. | Evans, MJ., et al. 2011. Proc Natl Acad Sci U S A. 108: 9578-82. PMID: 21606347
- Advances in small molecule inhibitors of androgen receptor for the treatment of advanced prostate cancer. | Sadar, MD. 2012. World J Urol. 30: 311-8. PMID: 21833557
- Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. | El Gendy, MA., et al. 2012. Toxicol Lett. 208: 51-61. PMID: 22001777
- Label-free fluorescence detection of aromatic compounds in chip electrophoresis applying two-photon excitation and time-correlated single-photon counting. | Beyreiss, R., et al. 2013. Anal Chem. 85: 8150-7. PMID: 23944704
- Fast determination of harmala alkaloids in edible algae by capillary electrophoresis mass spectrometry. | Tascon, M., et al. 2015. Anal Bioanal Chem. 407: 3637-45. PMID: 25749794
- A Water-Soluble Perylene Bisimide Cyclophane as a Molecular Probe for the Recognition of Aromatic Alkaloids. | Sapotta, M., et al. 2019. Angew Chem Int Ed Engl. 58: 3516-3520. PMID: 30576044
- High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor. | Dellal, H., et al. 2020. Cells. 9: PMID: 32560058
- Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes. | Andersson, B., et al. 1979. Biochem J. 184: 709-11. PMID: 540060
- The metabolism of cyclophosphamide by isolated rat hepatocytes. | Bates, DJ., et al. 1981. Biochem Pharmacol. 30: 3055-63. PMID: 7337723
- Phenolsulphotransferase activity in the developing mosquito (Aedes togoi) | Kim Ping Wong 1, B.C. Ho 2. 1986. Insect Biochemistry. 16: 293-297.
Inhibitor of:
Dyrk2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Harmol Hydrochloride, 10 mg | sc-295137B | 10 mg | $20.00 | |||
Harmol Hydrochloride, 100 mg | sc-295137 | 100 mg | $41.00 | |||
Harmol Hydrochloride, 500 mg | sc-295137A | 500 mg | $102.00 |