Date published: 2025-10-14
Visit Santa Cruz Animal Health

1-800-457-3801

SCBT Portrait Logo
Seach Input
Contact Us
Sign In Account
Quick Order
Cart (0)
Poly-L-Lysine Solution (CAS 25988-63-0) - chemical structure image
Molecular structure of Poly-L-Lysine Solution, CAS Number: 25988-63-0
Poly-L-Lysine Solution (CAS 25988-63-0) - chemical structure image
Molecular structure of Poly-L-Lysine Solution, CAS Number: 25988-63-0
Molecular structure of Poly-L-Lysine Solution, CAS Number: 25988-63-0

Poly-L-Lysine Solution (CAS 25988-63-0)

4.7(3)
Write a reviewAsk a question

See product citations (13)

Application:
Poly-L-Lysine Solution is an adhesive subbing solution for immunoperoxidase and routine histologic staining preparations
CAS Number:
25988-63-0
Molecular Weight:
150,000-300,000
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis

Poly-L-Lysine Solution is a positively charged amino acid polymer which has approximately one HBr per lysine residue. A small amount of this product may be found in the beta structure because the HBr interferes with hydrogen bonding between amino and either the carboxyl groups or N or O containing moieties. Poly-L-Lysine Solution polymers can be used in promoting cell adhesion to solid substrates, conjugation to methotrexate for increased drug transport, microencapsulation of islets, cell microencapsulation technology, microarray glass slide coating, and chromosomal preparations.


Poly-L-Lysine Solution (CAS 25988-63-0) References

  1. Appearance of highly sensitive cells to L-type Ca antagonist in cultured cerebellar granule cells.  |  Taya, K., et al. 1999. Nihon Shinkei Seishin Yakurigaku Zasshi. 19: 133-8. PMID: 10681157
  2. Application of poly-L-lysine to purification of leukocyte cathepsin G by affinity chromatography.  |  Nagamatsu, Y., et al. 1992. Chem Pharm Bull (Tokyo). 40: 1634-6. PMID: 1394685
  3. Electrochemical measurement of phenothiazine-interacted DNA.  |  Yabuki, S. and Mizutani, F. 2004. Bioelectrochemistry. 63: 253-5. PMID: 15110282
  4. Surface modification and characterization of chitosan film blended with poly-L-lysine.  |  Mingyu, C., et al. 2004. J Biomater Appl. 19: 59-75. PMID: 15245644
  5. Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments.  |  Sun, PZ., et al. 2005. J Magn Reson. 175: 193-200. PMID: 15893487
  6. Preparation of slides and coverslips for microscopy.  |  Fischer, AH., et al. 2008. CSH Protoc. 2008: pdb.prot4988. PMID: 21356831
  7. Detection of DNA and poly-l-lysine using CVD graphene-channel FET biosensors.  |  Kakatkar, A., et al. 2015. Nanotechnology. 26: 125502. PMID: 25741743
  8. Triboelectric charging sequence induced by surface functionalization as a method to fabricate high performance triboelectric generators.  |  Shin, SH., et al. 2015. ACS Nano. 9: 4621-7. PMID: 25844938
  9. The cellular response of nerve cells on poly-l-lysine coated PLGA-MWCNTs aligned nanofibers under electrical stimulation.  |  Wang, J., et al. 2018. Mater Sci Eng C Mater Biol Appl. 91: 715-726. PMID: 30033306
  10. Measurement of Secondary Structure Changes in Poly-L-lysine and Lysozyme during Acoustically Levitated Single Droplet Drying Experiments by In Situ Raman Spectroscopy.  |  Perlitz, JFA., et al. 2022. Sensors (Basel). 22: PMID: 35161856
  11. The application of surface tension measurements to the study of conformational transitions in aqueous solutions of poly-L-lysine.  |  Neumann, AW., et al. 1973. Biopolymers. 12: 1945-57. PMID: 4744745
  12. Cellular Pathology Technique  |  C. F. A. Culling, et al. 1985. 4.
  13. Bancroft's Theory And Practice Of Histological Techniques  |  John D. Bancroft. 1985. Butterworth & Co. 98.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Poly-L-Lysine Solution, 100 ml

sc-286689
100 ml
$165.00

Poly-L-Lysine Solution, 500 ml

sc-286689A
500 ml
$530.00

Is this product supplied sterile?

Asked by: andrea
Thank you for your question. This product is of technical grade quality and is not sterile.
Answered by: Tech Support Europe
Date published: 2023-11-24

Hello What is the molecular weight?

Asked by: Nancy 2021
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801 ext.1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-09-30

what is the concentration and price of Poly-L-Lysine Solution (CAS 25988-63-0) ?

Asked by: Anonymous
Thank you for your question. This product is supplied as 0.1 % (w/v) in H2O at volumes of either 100 ml or 500 ml (0.1 g and 0.5 g, respectively). Please contact customer care directly so we can provide you with a quotation for this product.
Answered by: Tech Support Europe
Date published: 2021-06-22

Does this product contain preservatives such as thimerosal?

Asked by: JR_NYC
Thank you for your question. Yes, this product contains 0.01% thimerosal as a preservative.
Answered by: Technical Support
Date published: 2020-03-11

Is this product suitable for cell culture use? Does it contain thimerosol or other preservative not suitable for cell culture?

Asked by: JR_NYC
This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood.
Answered by: Tech Service
Date published: 2022-04-04

Can you please provide a datasheet with RECOMMENDED COATING PROTOCOL and STORAGE AND RECONSTITUTION Thank you

Asked by: Researcher101
Thank you for your question. The concentration that this is supplied should be sufficient. Coating slides with this solution should be followed with a 5 minute incubation and drying the slides at room temperature. Coated slides will be stable for one year if protected from dust and stored according the MSDS conditions. Here is a link to a sample recent CoA and the SDS: http://datasheets.scbt.com/coa/coa.php?sc=sc-286689&lot=J2919 https://datasheets.scbt.com/sds/aghs/en/sc-286689.pdf
Answered by: Tech Service
Date published: 2020-02-20

Can this be used for tissue culture?

Asked by: Halle
Thank you very much for your inquiry. It has not been certified for cell culture. You can always run the solution through an appropriate filter if you want to sterilize it. Please do not hesitate to contact us again if you need any further information: uk@scbt.com
Answered by: Technical Support Europe
Date published: 2021-06-18

What is the recommended concentration to use for plate coating?

Asked by: Jz28sail
Thank you for your question. sc-286689, Poly-L-Lysine Solution is supplied at 0.1 % (w/v) in water and is ready to use for coating slides or plates.
Answered by: Chemical Support 5
Date published: 2017-11-22
  • y_2025, m_10, d_9, h_7CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_8
  • loc_en_US, sid_286689, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 116ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Perfecto!!!Los clientes están muy conformes con el producto.-
Date published: 2017-10-30
Rated 5 out of 5 by from Our lab uses this for IHC and good qualityOur lab uses this for IHC and good quality solution.
Date published: 2015-10-07
Rated 5 out of 5 by from Various publications cite the use of PolyVarious publications cite the use of Poly-L-Lysine Solution as an adhesive subbing solution for immunoperoxidase and routine histologic staining preparations. -SCBT Publication Review
Date published: 2015-03-28
  • y_2025, m_10, d_9, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_en_US, sid_286689, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 14ms
  • REVIEWS, PRODUCT
Poly-L-Lysine Solution is rated 4.7 out of 5 by 3.
  • y_2025, m_10, d_9, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_en_US, sid_286689, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 103ms
  • REVIEWS, PRODUCT
1-800-457-3801
Visit Santa Cruz Animal Health|Visit San Juan Ranch
Santa Cruz Animal Health is a leading provider of animal health care products. ©2025 Santa Cruz Biotechnology Inc. All Rights Reserved.
Toll-Free: (800) 457-3801 - Terms & Conditions | Privacy Policy | Legal
“Santa Cruz Animal Health”, “San Juan Ranch”, the San Juan Ranch logo, “UltraCruz”, “Supplement of Champions”, are registered trademarks of Santa Cruz Biotechnology, Inc. All other trademarks are the property of their respective owners.