Date published: 2026-4-20

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Casticin (CAS 479-91-4)

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Alternate Names:
Vitexicarpin
Application:
Casticin is a tubulin-binding anticancer flavonoid
CAS Number:
479-91-4
Purity:
≥99%
Molecular Weight:
374.34
Molecular Formula:
C19H18O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Casticin is a compound that has interest in various research disciplines, particularly in the study of signal transduction pathways. In cellular biology, casticin is a subject of interest due to its influence on several types of cell signaling cascades, providing insights into the intricate mechanisms of cellular communication and regulation. Research involving casticin also extends to the realm of plant sciences, where it is studied for its role in the regulation of plant growth and development, as well as its potential impact on plant defense mechanisms. Additionally, casticin is used in the field of analytical chemistry, where it serves as a reference compound in chromatographic analyses of plant extracts. The chemical′s interaction with light and its fluorescence properties make casticin a useful tool in photophysical studies, aiding in the understanding of molecular behavior under various conditions.


Casticin (CAS 479-91-4) References

  1. Molecular mechanisms of casticin action: an update on its antitumor functions.  |  Rasul, A., et al. 2014. Asian Pac J Cancer Prev. 15: 9049-58. PMID: 25422178
  2. Casticin Inhibits A375.S2 Human Melanoma Cell Migration/Invasion through Downregulating NF-κB and Matrix Metalloproteinase-2 and -1.  |  Wu, ZY., et al. 2016. Molecules. 21: 384. PMID: 27007357
  3. Casticin inhibits lipopolysaccharide-induced acute lung injury in mice.  |  Wang, C., et al. 2016. Eur J Pharmacol. 789: 172-178. PMID: 27450485
  4. Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties.  |  Chan, EWC., et al. 2018. J Integr Med. 16: 147-152. PMID: 29559215
  5. Casticin protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes.  |  Mu, Y., et al. 2019. Eur J Pharmacol. 842: 314-320. PMID: 30391743
  6. Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway.  |  Fan, L., et al. 2018. Biosci Rep. 38: PMID: 30401729
  7. Casticin inhibits invasion and proliferation via downregulation of β-catenin and reversion of EMT in oral squamous cell carcinoma.  |  Xie, Y., et al. 2019. J Oral Pathol Med. 48: 897-905. PMID: 31318467
  8. Casticin inhibits human prostate cancer DU 145 cell migration and invasion via Ras/Akt/NF-κB signaling pathways.  |  Lin, CC., et al. 2019. J Food Biochem. 43: e12902. PMID: 31353708
  9. Casticin inhibits nasopharyngeal carcinoma growth by targeting phosphoinositide 3-kinase.  |  Liu, J., et al. 2019. Cancer Cell Int. 19: 348. PMID: 31889900
  10. Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.  |  Chu, J., et al. 2020. Inflammation. 43: 810-820. PMID: 31897918
  11. Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling.  |  Li, X., et al. 2020. Int Immunopharmacol. 86: 106745. PMID: 32622201
  12. Casticin protected against neuronal injury and inhibited the TLR4/NF-κB pathway after middle cerebral artery occlusion in rats.  |  Huang, D., et al. 2021. Pharmacol Res Perspect. 9: e00752. PMID: 33704926
  13. Antifibrotic and anthelminthic effect of casticin on Schistosoma mansoni-infected BALB/c mice.  |  Lam, HYP., et al. 2022. J Microbiol Immunol Infect. 55: 314-322. PMID: 34167886
  14. Casticin Impacts Key Signaling Pathways in Colorectal Cancer Cells Leading to Cell Death with Therapeutic Implications.  |  Kowalski, M., et al. 2022. Genes (Basel). 13: PMID: 35627200

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Casticin, 10 mg

sc-281634
10 mg
$544.00