Date published: 2025-9-17

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ZWITTERGENT 3-12 Detergent (CAS 14933-08-5)

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Alternate Names:
Lauryl sultaine; Dodecyldimethyl(3-sulfopropyl)ammonium Hydroxide Inner Salt
Application:
ZWITTERGENT 3-12 Detergent is useful for protein solubilization
CAS Number:
14933-08-5
Purity:
≥98%
Molecular Weight:
335.54
Molecular Formula:
C17H37NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zwittergent 3-12 Detergent is a surfactant, or surface-active agent, that is widely utilized in laboratory experiments and industrial applications. This compound is classified as a quaternary ammonium salt, which are frequently employed as detergents and antiseptics. It has a broad range of applications, from cleaning to industrial processes. Zwittergent 3-12 Detergent can act as a stabilizing agent in aqueous solutions and also as a surfactant in cell culture media. It has the additional ability to serve as a solubilizer for hydrophobic molecules and as a chelating agent for metal ions. Furthermore, it can stabilize enzymes, and act as a surfactant in chromatography.


ZWITTERGENT 3-12 Detergent (CAS 14933-08-5) References

  1. Structure of the Rhodobacter sphaeroides light-harvesting 1 beta subunit in detergent micelles.  |  Sorgen, PL., et al. 2002. Biochemistry. 41: 31-41. PMID: 11772000
  2. An evaluation of detergents for NMR structural studies of membrane proteins.  |  Krueger-Koplin, RD., et al. 2004. J Biomol NMR. 28: 43-57. PMID: 14739638
  3. The effect of detergents on the purified flavin-containing monooxygenase of mouse liver, kidney and lungs.  |  Venkatesh, K., et al. 1991. Gen Pharmacol. 22: 549-52. PMID: 1651268
  4. Structural stability of hepatitis C virus envelope glycoprotein E1: effect of pH and dissociative detergents.  |  He, F., et al. 2009. J Pharm Sci. 98: 3340-57. PMID: 19072857
  5. Rapid and sensitive sandwich enzyme-linked immunosorbent assay for detection of staphylococcal enterotoxin B in cheese.  |  Morissette, C., et al. 1991. Appl Environ Microbiol. 57: 836-42. PMID: 2039234
  6. Potential of the sulfobetaine detergent Zwittergent 3-12 as a desorbing agent in biospecific and bioselective affinity chromatography.  |  Nollstadt, KH., et al. 1989. J Chromatogr. 497: 87-100. PMID: 2625482
  7. Impact of Detergents on Membrane Protein Complex Isolation.  |  Lee, YC., et al. 2018. J Proteome Res. 17: 348-358. PMID: 29110486
  8. Detergent-assisted refolding of guanidinium chloride-denatured rhodanese. The effects of the concentration and type of detergent.  |  Tandon, S. and Horowitz, PM. 1987. J Biol Chem. 262: 4486-91. PMID: 3470292
  9. Solubilization of prolactin receptor by a Zwitterionic detergent.  |  Church, WR. and Ebner, KE. 1982. Experientia. 38: 434-5. PMID: 6282617
  10. Binding of fibronectin to gelatin and heparin: effect of surface denaturation and detergents.  |  Haas, R. and Culp, LA. 1984. FEBS Lett. 174: 279-83. PMID: 6468662
  11. Solubilization of membrane-bound ribonuclease (RNAse) and alkaline phosphatase from the isolated brush border of Hymenolepis diminuta (Cestoda).  |  Gamble, HR. and Pappas, PW. 1980. J Parasitol. 66: 434-8. PMID: 7391887
  12. Characterization of a porin from Mycobacterium smegmatis.  |  Mukhopadhyay, S., et al. 1997. J Bacteriol. 179: 6205-7. PMID: 9324274
  13. Spectroscopic and hydrodynamic investigations of nonionic and zwitterionic detergents  |  , et al. 01 January 1999. Analytical Ultracentrifugation V pp.,volume 113): 135–141.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ZWITTERGENT 3-12 Detergent, 5 g

sc-281192
5 g
$93.00

ZWITTERGENT 3-12 Detergent, 25 g

sc-281192A
25 g
$245.00

What is the (lower) temperature limit for solubility of Zwittergent 3-12 in water? What is the stability of a solution of 0.001% Ztn 3-12 in water? Is there data for stability up to at least 8 degrees C for up to 24 hrs?

Asked by: Katy
Thank you for your question. A lower limit for temperature for solubility has not been determined. This compound is known to be stable in solution up to 1 month when stored at 4ºC.
Answered by: Technical Service
Date published: 2024-07-31
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Rated 5 out of 5 by from Various publications cite the use of ZWITTERGENT 3Various publications cite the use of ZWITTERGENT 3-12 Detergent for protein solubilization. -SCBT Publication Review
Date published: 2015-01-08
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ZWITTERGENT 3-12 Detergent is rated 5.0 out of 5 by 1.
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