Molecular structure of Oxaloacetic Acid, CAS Number: 328-42-7
Oxaloacetic Acid (CAS 328-42-7)
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Application:
Oxaloacetic Acid is a malate dehydrogenase and oxaloacetate decarboxylase substrate
CAS Number:
328-42-7
Purity:
≥98%
Molecular Weight:
132.1
Molecular Formula:
C4H4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH. Oxaloacetic acid plays a role as a metabolic intermediate in various biochemical pathways, including the citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Additionally, it exhibits a strong affinity for binding metal ions such as copper, zinc, and iron, forming stable chelates with these metals.
Oxaloacetic Acid (CAS 328-42-7) References
- The production of pyruvic acid, oxaloacetic acid and alpha-oxoglutaric acid from glucose by tissue in culture. | ABDEL-TAWAB, GA., et al. 1959. Biochem J. 72: 619-23. PMID: 13791409
- A micromethod for the estimation of oxaloacetic acid in tissues. | BERTOLE, ML. and FORTI, G. 1962. Biochim Biophys Acta. 62: 596-8. PMID: 13868451
- Kinetic mechanism and structural requirements of the amine-catalyzed decarboxylation of oxaloacetic acid. | Thalji, NK., et al. 2009. J Org Chem. 74: 144-52. PMID: 19035664
- Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. | Strong, R., et al. 2013. J Gerontol A Biol Sci Med Sci. 68: 6-16. PMID: 22451473
- Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats. | Shibata, K., et al. 2013. J Nutr Sci Vitaminol (Tokyo). 59: 509-15. PMID: 24477247
- Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment. | Ruban, A., et al. 2015. Neurodegener Dis. 15: 233-42. PMID: 26113413
- The effect of oxaloacetic acid on tyrosinase activity and structure: Integration of inhibition kinetics with docking simulation. | Gou, L., et al. 2017. Int J Biol Macromol. 101: 59-66. PMID: 28322963
- Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. | Fink, BD., et al. 2018. J Biol Chem. 293: 19932-19941. PMID: 30385511
- Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect. | Wiese, EK., et al. 2021. Nat Metab. 3: 954-968. PMID: 34226744
- Experimental and Theoretical Studies of Dissociative Electron Attachment to Metabolites Oxaloacetic and Citric Acids. | Kopyra, J., et al. 2021. Int J Mol Sci. 22: PMID: 34299296
- 6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species. | Ma, N., et al. 2022. Phytomedicine. 102: 154164. PMID: 35597026
- Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction. | Li, W., et al. 2022. Front Pharmacol. 13: 1029775. PMID: 36313362
- Selectivity in the metal-complex-catalyzed decarboxylation of oxaloacetic acid and a role of metal ion in an enzyme system. | Munakata, M., et al. 1970. Bull Chem Soc Jpn. 43: 114-8. PMID: 5436363
Inhibitor of:
BDH1, Citrate Lyase, Enzyme, FAHD2A, Gulo, IDH3B, IRG1, L-Malate Dehydrogenase, LOC283398, MDH2, ME2, MIBP, OGDHL, PGAM4, SDH, SDHA, SDHD, SEDL, SQRDL, and SUCLG1.Activator of:
ζ-crystallin, AASS, AATM, Acetyl-CoA Synthetase, ACO2, Aldolase A, ATP-citrate synthase, BCKDHB, Biotin-NHS, C10orf65, CDO, DHRS2, DLD, E3BP, ECHS1, EG240549, ENOSF1, Ep-CAM, FAHD1, Fatso, GLYAT, GOT1L1, GPD2, GRHPR, IDH3G, IDHC, ME2, MMD2, OTA, PDSS1, Phosphotransacetylase, PI 3-kinase p85α, PPC-DC, RMND1, SKIV2L2, and SUCO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxaloacetic Acid, 25 g | sc-279934 | 25 g | $300.00 | |||
Oxaloacetic Acid, 100 g | sc-279934A | 100 g | $944.00 | |||
Oxaloacetic Acid, 1 kg | sc-279934B | 1 kg | $7824.00 |