Date published: 2025-9-19

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N-Acetyl-L-tyrosine (CAS 537-55-3)

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Alternate Names:
Ac-Tyr-OH
Application:
N-Acetyl-L-tyrosine is a derivative of tyrosine involved in catecholamine production
CAS Number:
537-55-3
Purity:
≥99%
Molecular Weight:
223.23
Molecular Formula:
C11H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Acetyl-L-tyrosine, or NALT, is a modified form of tyrosine, an essential amino acid present in proteins. This modification involves the addition of an acetyl group. N-Acetyl-L-tyrosine has been utilized in diverse scientific investigations, including those studying the effects of stress and the role of tyrosine in the central nervous system. It′s been used in research exploring the impacts of aging on cognitive performance and in examining tyrosine′s role in learning and memory processes. Additionally, N-Acetyl-L-tyrosine has been employed in studies investigating the influence of certain substances on cognitive performance and in probing the action mechanisms of various substances. N-Acetyl-L-tyrosine serves as a precursor to the neurotransmitter dopamine, and is thought to boost dopamine availability in the brain by accelerating dopamine synthesis. It′s also believed to raise the levels of norepinephrine and epinephrine, which play integral roles in mood and behavior regulation.


N-Acetyl-L-tyrosine (CAS 537-55-3) References

  1. 15N chemically induced dynamic nuclear polarization during reaction of N-acetyl-L-tyrosine with the nitrating systems nitrite/hydrogen peroxide/horseradish peroxidase and nitrite/hypochloric acid.  |  Lehnig, M. 2001. Arch Biochem Biophys. 393: 245-54. PMID: 11556811
  2. KINETICS OF IODINATION. II. GENERAL BASE CATALYSIS IN THE IODINATION OF N-ACETYL-L-TYROSINE AND N-ACETYL-3-IODO-L-TYROSINE.  |  MAYBERRY, WE. and BERTOLI, DA. 1965. J Org Chem. 30: 2029-34. PMID: 14325496
  3. N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition.  |  Hoffer, LJ., et al. 2003. JPEN J Parenter Enteral Nutr. 27: 419-22. PMID: 14621123
  4. N-acetyl tyrosyluria caused by parenteral or enteral administration of N-acetyl-L-tyrosine: differentiation from hereditary and acquired tyrosinemias.  |  Korman, SH. and Gutman, A. 2004. J Pediatr Gastroenterol Nutr. 39: 95-100. PMID: 15187789
  5. N-Acetyl-3,5-dibromo-l-tyrosine hemihydrate.  |  Bovonsombat, P., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: o2601-2. PMID: 22969507
  6. N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans.  |  Magnusson, I., et al. 1989. Metabolism. 38: 957-61. PMID: 2507878
  7. Brain tyrosine increases after treating with prodrugs: comparison with tyrosine.  |  Topall, G. and Laborit, H. 1989. J Pharm Pharmacol. 41: 789-91. PMID: 2576051
  8. Phenol red-silk tyrosine cross-linked hydrogels.  |  Sundarakrishnan, A., et al. 2016. Acta Biomater. 42: 102-113. PMID: 27345138
  9. Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa.  |  Słominski, A., et al. 1988. J Cell Sci. 89 (Pt 3): 287-96. PMID: 3143738
  10. N-acetyl-l-tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals.  |  Matsumura, T., et al. 2020. EMBO Rep. 21: e49211. PMID: 32118349
  11. N-acetyl-L-tyrosine as a tyrosine source during total parenteral nutrition in adult rats.  |  Im, HA., et al. 1985. Pediatr Res. 19: 514-8. PMID: 3925425
  12. Utilization of N-acetyl-L-tyrosine and glycyl-L-tyrosine during long-term parenteral nutrition in the growing rat.  |  Neuhäuser, M., et al. 1985. Am J Clin Nutr. 42: 585-96. PMID: 3931451
  13. Mechanism of nasal absorption of drugs. II: Absorption of L-tyrosine and the effect of structural modification on its absorption.  |  Huang, CH., et al. 1985. J Pharm Sci. 74: 1298-301. PMID: 4087196
  14. Purification and properties of thermostable N-acylamino acid racemase from Amycolatopsis sp. TS-1-60.  |  Tokuyama, S. and Hatano, K. 1995. Appl Microbiol Biotechnol. 42: 853-9. PMID: 7766084
  15. N-acetyl-L-tyrosine (NAT) as a substrate for mushroom tyrosinase.  |  Kahn, V. and Ben-Shalom, N. 1998. Pigment Cell Res. 11: 24-33. PMID: 9523332

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Acetyl-L-tyrosine, 25 g

sc-279678
25 g
$95.00