Date published: 2025-11-20

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Protopine hydrochloride (CAS 6164-47-2)

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Application:
Protopine hydrochloride is a light-sensitive calcium channel protein inhibitor
CAS Number:
6164-47-2
Purity:
98%
Molecular Weight:
389.83
Molecular Formula:
C20H19NO5•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Protopine hydrochloride is an alkaloid salt, which is primarily of interest in the field of natural product chemistry and botanical studies. As a compound found in several plant species, such as those from the Fumariaceae and Papaveraceae families, it serves as a model for understanding the biosynthesis and ecological role of alkaloids. In analytical research, Protopine hydrochloride is used as a reference substance to identify and quantify the presence of protopine in plant extracts through techniques like high-performance liquid chromatography (HPLC). It also plays a role in the study of plant defense mechanisms, as alkaloids like protopine are known to have bioactive properties that may deter herbivores or inhibit the growth of pathogens. Additionally, Protopine hydrochloride is utilized in biochemical research to explore its interaction with various cellular and molecular targets, contributing to a broader understanding of the biological activities of alkaloid compounds.


Protopine hydrochloride (CAS 6164-47-2) References

  1. Ca(2+)-channel blockade in rat thoracic aorta by protopine isolated from Corydalis tubers.  |  Ko, FN., et al. 1992. Jpn J Pharmacol. 58: 1-9. PMID: 1322473
  2. Theoretical and experimental NMR study of protopine hydrochloride isomers.  |  Tousek, J., et al. 2005. Magn Reson Chem. 43: 578-81. PMID: 15883981
  3. Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata.  |  Lee, KH., et al. 2005. Exp Mol Med. 37: 371-7. PMID: 16155414
  4. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.  |  Xu, LF., et al. 2006. Neuropharmacology. 50: 934-40. PMID: 16530230
  5. Extractions of isoquinoline alkaloids with butanol and octanol.  |  Gregorová, J., et al. 2010. Fitoterapia. 81: 565-8. PMID: 20117181
  6. Pharmacological efficacy of argemone mexicana plant extract, against cysteamine-induced duodenal ulceration in rats.  |  Das, PK., et al. 2011. Indian J Med Sci. 65: 92-9. PMID: 23250289
  7. Capillary electrophoretic study of the synergistic biological effects of alkaloids from Chelidonium majus L. in normal and cancer cells.  |  Kulp, M. and Bragina, O. 2013. Anal Bioanal Chem. 405: 3391-7. PMID: 23358674
  8. Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.  |  Moser, C., et al. 2014. Phytomedicine. 21: 1382-9. PMID: 25022210
  9. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors.  |  Fedurco, M., et al. 2015. Biochem Res Int. 2015: 617620. PMID: 26509084
  10. Intestinal anti-inflammatory effects of total alkaloid extract from Fumaria capreolata in the DNBS model of mice colitis and intestinal epithelial CMT93 cells.  |  Bribi, N., et al. 2016. Phytomedicine. 23: 901-13. PMID: 27387398
  11. Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry.  |  Contreras, MDM., et al. 2017. Int J Anal Chem. 2017: 5178729. PMID: 29348751
  12. Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice.  |  Yuan, J., et al. 2020. Phytomedicine. 76: 153264. PMID: 32570112
  13. An ultra-high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous quantitation of 10 alkaloids of Corydalis Decumbentis Rhizoma preparation in dog plasma and its application to a pharmacokinetic study.  |  Yu, Y., et al. 2023. Basic Clin Pharmacol Toxicol. 132: 33-50. PMID: 36303263

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Protopine hydrochloride, 5 mg

sc-272121
5 mg
$316.00