trans,trans-Farnesol (CAS 106-28-5)
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Trans,trans-Farnesol, a naturally-occurring sesquiterpene alcohol, is found in plant extracts. This colorless, oily liquid possesses a delicate aroma reminiscent of roses. It is widely distributed in various organisms and the environment. Researchers have extensively investigated trans,trans-Farnesol for its potential, revealing its ability to combat inflammation, microbial infections, and cancer. Moreover, its antioxidant properties and gene expression modulation capabilities have been widely studied. Additional trans,trans-Farnesol functionality include the inhibition of specific enzymes involved in the inflammatory response, such as cyclooxygenase-2 (COX-2). Furthermore, trans,trans-Farnesol impedes the growth of bacteria, viruses, and fungi, displaying anti-microbial properties. Its anti-cancer activity manifests through the induction of apoptosis in cancer cells. Lastly, trans,trans-Farnesol demonstrates the ability to modulate gene expression and acts as an antioxidant.
trans,trans-Farnesol (CAS 106-28-5) References
- Hydrolysis and isomerization of trans,trans-farnesyl diphosphate by Andrographis tissue-culture enzymes. | Mackie, H. and Overton, KH. 1977. Eur J Biochem. 77: 101-6. PMID: 198206
- Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms. | Jeon, JG., et al. 2011. Int J Oral Sci. 3: 98-106. PMID: 21485314
- Study of trans-trans farnesol effect on hyphae formation by Yarrowia lipolytica. | Nunes, PM., et al. 2013. Bioprocess Biosyst Eng. 36: 1967-75. PMID: 23715764
- Assessment of the antioxidant and antiproliferative effects of sesquiterpenic compounds in in vitro Caco-2 cell models. | Vinholes, J., et al. 2014. Food Chem. 156: 204-11. PMID: 24629959
- Release behavior of trans,trans-farnesol entrapped in amorphous silica capsules. | Sousa, FL., et al. 2012. Results Pharma Sci. 2: 52-6. PMID: 25755994
- Effect of Trans, Trans-Farnesol on Pseudogymnoascus destructans and Several Closely Related Species. | Raudabaugh, DB. and Miller, AN. 2015. Mycopathologia. 180: 325-32. PMID: 26162644
- Purification and Characterization of a Novel NAD(P)+-Farnesol Dehydrogenase from Polygonum minus Leaves. | Ahmad-Sohdi, NA., et al. 2015. PLoS One. 10: e0143310. PMID: 26600471
- Trans, trans-farnesol as a mevalonate-derived inducer of murine 3T3-F442A pre-adipocyte differentiation. | Torabi, S. and Mo, H. 2016. Exp Biol Med (Maywood). 241: 493-500. PMID: 26660152
- Trans,trans-farnesol, an antimicrobial natural compound, improves glass ionomer cement properties. | de Castilho, ARF., et al. 2019. PLoS One. 14: e0220718. PMID: 31430298
- Purification, biochemical characterisation and bioinformatic analysis of recombinant farnesol dehydrogenase from Theobroma cacao. | Satyaveanthan, MV., et al. 2021. Plant Physiol Biochem. 161: 143-155. PMID: 33588320
- Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health. | Lopes, AP., et al. 2021. Bioorg Med Chem Lett. 47: 128192. PMID: 34118413
- Possible mechanisms involved in the neuroprotective effect of Trans,trans-farnesol on pilocarpine-induced seizures in mice. | Araújo Delmondes, G., et al. 2022. Chem Biol Interact. 365: 110059. PMID: 35931201
- Biosynthesis of trans, trans- and cis, trans-farnesols by soluble enzymes from tissue cultures of Andrographis paniculata. | Overton, KH. and Roberts, FM. 1974. Biochem J. 144: 585-92. PMID: 4468823
- Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. | Bondar, OP., et al. 1994. Chem Phys Lipids. 74: 93-8. PMID: 7820904
- Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. | Haug, JS., et al. 1994. Biochim Biophys Acta. 1223: 133-40. PMID: 8061045
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
trans,trans-Farnesol, 1 g | sc-258277 | 1 g | $29.00 |