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DL-Norleucine (CAS 616-06-8)

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Alternate Names:
(±)-2-Aminocaproic acid, 2-Aminohexanoic acid
CAS Number:
616-06-8
Molecular Weight:
131.17
Molecular Formula:
C6H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DL-Norleucine, a chiral amino acid derivative, has been extensively employed in scientific research since the early 1960s. It serves as a valuable building block for the synthesis of peptides and proteins. Although it is not utilized in the body′s natural protein synthesis, DL-Norleucine finds application as a reagent in the synthesis of various compounds, including amino acids and peptides. Moreover, its versatility extends to being used as a substrate in enzyme assays and as a fluorescent probe in cell-based assays.


DL-Norleucine (CAS 616-06-8) References

  1. Burkholderia fungorum sp. nov. and Burkholderia caledonica sp. nov., two new species isolated from the environment, animals and human clinical samples.  |  Coenye, T., et al. 2001. Int J Syst Evol Microbiol. 51: 1099-1107. PMID: 11411678
  2. Amino acid cross resistance in Agrobacterium tumefaciens.  |  BEARDSLEY, RE. 1962. J Bacteriol. 84: 1237-40. PMID: 13969951
  3. Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores.  |  LEVINSON, HS. and HYATT, MT. 1962. J Bacteriol. 83: 1224-30. PMID: 14464681
  4. Concerted molecular displacements in a thermally-induced solid-state transformation in crystals of DL-norleucine.  |  Anwar, J., et al. 2007. J Am Chem Soc. 129: 2542-7. PMID: 17286403
  5. Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAHENU2 mice.  |  Vogel, KR., et al. 2013. J Inherit Metab Dis. 36: 513-23. PMID: 22976763
  6. Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis.  |  Rastogi, N., et al. 1990. Antimicrob Agents Chemother. 34: 759-64. PMID: 2360816
  7. Methionine as methyl-group donor in the synthesis of Mycobacterium avium envelope lipids, and its inhibition by DL-ethionine, D-norleucine and DL-norleucine.  |  David, HL., et al. 1989. Acta Leprol. 7 Suppl 1: 77-80. PMID: 2504011
  8. Do solid-to-solid polymorphic transitions in DL-norleucine proceed through nucleation?  |  van den Ende, JA., et al. 2015. Faraday Discuss. 179: 421-36. PMID: 25880981
  9. Terahertz Spectroscopy and Density Functional Theory Calculations of dl-Norleucine and dl-Methionine.  |  Neu, J., et al. 2018. J Phys Chem A. 122: 5978-5982. PMID: 29894636
  10. Simulation of diffuse scattering in DL-norleucine.  |  Welberry, TR. and Görbitz, CH. 2019. Acta Crystallogr B Struct Sci Cryst Eng Mater. 75: 393-405. PMID: 32830661
  11. Interference by methionine on valine uptake in Acremonium chrysogenum.  |  Alonso, MJ. and Luengo, JM. 1987. Antimicrob Agents Chemother. 31: 357-9. PMID: 3566258
  12. Sulfur metabolism of a mutant of Cephalosporium acremonium with enhanced potential to utilize sulfate for cephalosporin C production.  |  Komatsu, KI. and Kodaira, R. 1977. J Antibiot (Tokyo). 30: 226-33. PMID: 558969
  13. Effect of inhibitors of cell envelope synthesis on beta-sitosterol side chain degradation by Mycobacterium sp. NRRL MB 3683.  |  Sedlaczek, L., et al. 1994. J Basic Microbiol. 34: 387-99. PMID: 7815307
  14. Effect of norleucine on mycelial fragmentation in Cephalosporium acremonium.  |  Drew, SW., et al. 1976. Appl Environ Microbiol. 31: 143-5. PMID: 945975

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DL-Norleucine, 5 g

sc-257399
5 g
$38.00

DL-Norleucine, 25 g

sc-257399A
25 g
$57.00