Molecular structure of Isoliquiritigenin, CAS Number: 961-29-5
Isoliquiritigenin (CAS 961-29-5)
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Alternate Names:
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Application:
Isoliquiritigenin is a GCS (soluble guanylyl cyclase) activator
CAS Number:
961-29-5
Purity:
≥97%
Molecular Weight:
256.25
Molecular Formula:
C15H12O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Isoliquiritigenin functions as a potent antioxidant in experimental applications. It exerts its mechanism of action by scavenging free radicals and inhibiting oxidative stress at the molecular level. Isoliquiritigenin also demonstrates anti-inflammatory properties by modulating the activity of various inflammatory mediators and signaling pathways. Isoliquiritigenin may regulate the expression of genes involved in inflammation and oxidative stress, contributing to its functional role as a bioactive compound. It may modulate cellular signaling pathways, including those related to cell proliferation and apoptosis, further highlighting its significance in experimental applications.
Isoliquiritigenin (CAS 961-29-5) References
- Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation. | Lu, H., et al. 2013. Fitoterapia. 84: 208-12. PMID: 23237733
- Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism. | Lee, YK., et al. 2013. Planta Med. 79: 1656-65. PMID: 24108436
- Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. | Honda, H., et al. 2014. J Leukoc Biol. 96: 1087-100. PMID: 25210146
- Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine. | Zhao, Z., et al. 2015. Chem Biol Interact. 225: 13-20. PMID: 25450236
- A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. | Gong, H., et al. 2015. J Ethnopharmacol. 162: 134-9. PMID: 25557030
- Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans. | Link, P., et al. 2015. Planta Med. 81: 357-62. PMID: 25782036
- In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. | Choi, YH., et al. 2015. Planta Med. 81: 586-93. PMID: 25875506
- A Review: The Pharmacology of Isoliquiritigenin. | Peng, F., et al. 2015. Phytother Res. 29: 969-77. PMID: 25907962
- Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation. | Wang, N., et al. 2015. Oncotarget. 6: 9854-76. PMID: 25918249
- Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell. | Li, ZX., et al. 2015. Biochem Biophys Res Commun. 464: 548-53. PMID: 26159926
- Isoliquiritigenin Inhibits Interferon-γ-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways. | Wu, S., et al. 2015. Cell Physiol Biochem. 37: 501-14. PMID: 26315837
- Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells. | Zhao, S., et al. 2015. Int J Clin Exp Pathol. 8: 12577-82. PMID: 26722447
- Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis. | Mahalingam, S., et al. 2016. Reprod Toxicol. 66: 107-114. PMID: 27773742
- The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death. | Yang, EJ., et al. 2016. Bioorg Med Chem Lett. 26: 5639-5643. PMID: 27815122
Inhibitor of:
CARD 8, CYP7B1, Enzyme, GSTT4, NAIP2, NALP1B, NALP4A, NALP9, TNF-IP 1, and V1RF5.Activator of:
BC026590, GCS, GSTM4, Guanylate Cyclases, IL-1β, NALP11, Sir2, SIRT5, and TAB3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoliquiritigenin, 10 mg | sc-255222 | 10 mg | $310.00 |