Digitoxigenin (CAS 143-62-4)
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Digitoxigenin is a steroid compound that functions as a precursor in the synthesis of cardiac glycosides. It acts by inhibiting the sodium-potassium ATPase pump in cell membranes, leading to an increase in intracellular sodium and calcium levels. This, in turn, enhances cardiac contractility and promotes diuresis. At the molecular level, digitoxigenin binds to the ATPase pump, disrupting its normal function and leading to the accumulation of intracellular ions. This disruption of ion homeostasis ultimately results in the positive inotropic effect observed in cardiac tissue. Digitoxigenin may induce apoptosis in cancer cells by activating caspase-dependent pathways and inhibiting cell proliferation. Its ability to modulate ion transport and induce apoptosis makes digitoxigenin a useful for studying cellular signaling pathways and investigating potential targets.
Digitoxigenin (CAS 143-62-4) References
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- Chemical structure and pharmacological activity of some derivatives of digitoxigenin and digoxigenin. | BROWN, BT., et al. 1962. Br J Pharmacol Chemother. 18: 311-24. PMID: 13873586
- An LC-MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies. | Feng, X., et al. 2017. J Pharm Biomed Anal. 138: 378-385. PMID: 28139268
- Topical Digitoxigenin for Wound Healing: A Feasibility Study. | Feng, X., et al. 2018. Bioengineering (Basel). 5: PMID: 29510580
- The effect of 16 beta-substitution on the structure and activity of digitoxigenin: is there an additional binding interaction with Na+,K+-ATPase? | Griffin, JF., et al. 1986. Mol Pharmacol. 29: 270-4. PMID: 3005835
- Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives. | Boff, L., et al. 2019. Eur J Med Chem. 167: 546-561. PMID: 30798081
- New 99mTc-Labeled Digitoxigenin Derivative for Cancer Cell Identification. | Munkert, J., et al. 2019. ACS Omega. 4: 22048-22056. PMID: 31891085
- Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis. | Freitas, CS., et al. 2021. Parasitol Res. 120: 321-335. PMID: 33191446
- Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca2+ -ATPase. | Valadares, JMM., et al. 2021. J Cell Biochem. 122: 1903-1914. PMID: 34553411
- Digitoxigenin 3-O-beta-D-furanosides. | Prisbe, EJ., et al. 1986. J Med Chem. 29: 239-44. PMID: 3950906
- Bioavailability of the bis- and monodigitoxosides of digitoxigenin. | Fenster, PE., et al. 1985. Eur J Clin Pharmacol. 28: 649-52. PMID: 4065189
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- Digitoxigenin, a digitalis steroid, induces meiotic maturation of Xenopus laevis oocytes. | Cartaud, A., et al. 1984. J Steroid Biochem. 21: 101-6. PMID: 6087028
- Na+/K+ pump inhibition and positive inotropic effect of digitoxigenin and some C-22-substituted derivatives in sheep cardiac preparations. | Erlenkamp, S., et al. 1998. Naunyn Schmiedebergs Arch Pharmacol. 357: 54-62. PMID: 9459573
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Digitoxigenin, 10 mg | sc-255098 | 10 mg | $97.00 |