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5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7) - chemical structure image
Molecular structure of 5-Bromo-5-nitro-1,3-dioxane, CAS Number: 30007-47-7
5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7) - chemical structure image
Molecular structure of 5-Bromo-5-nitro-1,3-dioxane, CAS Number: 30007-47-7
Molecular structure of 5-Bromo-5-nitro-1,3-dioxane, CAS Number: 30007-47-7

5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7)

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Alternate Names:
Bronidox; m-DIOXANE
Application:
5-Bromo-5-nitro-1,3-dioxane is An antibacterial agent.
CAS Number:
30007-47-7
Molecular Weight:
212.00
Molecular Formula:
C4H6BrNO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis

5-Bromo-5-nitro-1,3-dioxane, also known as Bronidox, exhibits antimicrobial properties against a wide range of microorganisms including gram-negative and gram-positive bacteria, yeast, and fungi. 5-Bromo-5-nitro-1,3-dioxane is employed as a stabilizer and preservative in biological molecules and solutions, such as antibodies and antisera. It finds application in rinse-off cosmetics, where it serves as a preserving agent. Bronidox can be used alone or in combination with methylisothiazolone to enhance its effectiveness.


5-Bromo-5-nitro-1,3-dioxane (CAS 30007-47-7) References

  1. Analytical control of preservative labelling on skin creams.  |  Rastogi, SC. 2000. Contact Dermatitis. 43: 339-43. PMID: 11140384
  2. A survey of formaldehyde in shampoos and skin creams on the Danish market.  |  Rastogi, SC. 1992. Contact Dermatitis. 27: 235-40. PMID: 1451488
  3. N-nitrosoalkanolamines in cosmetics.  |  Eisenbrand, G., et al. 1991. IARC Sci Publ. 238-41. PMID: 1855860
  4. Formaldehyde-releasers: relationship to formaldehyde contact allergy. Contact allergy to formaldehyde and inventory of formaldehyde-releasers.  |  de Groot, AC., et al. 2009. Contact Dermatitis. 61: 63-85. PMID: 19706047
  5. Development of a solid-phase microextraction gas chromatography with microelectron-capture detection method for the determination of 5-bromo-5-nitro-1,3-dioxane in rinse-off cosmetics.  |  Fernandez-Alvarez, M., et al. 2010. J Chromatogr A. 1217: 6634-9. PMID: 20444463
  6. Analysis of multi-class preservatives in leave-on and rinse-off cosmetics by matrix solid-phase dispersion.  |  Sanchez-Prado, L., et al. 2011. Anal Bioanal Chem. 401: 3293-304. PMID: 21947013
  7. Development of a multi-preservative method based on solid-phase microextraction-gas chromatography-tandem mass spectrometry for cosmetic analysis.  |  Alvarez-Rivera, G., et al. 2014. J Chromatogr A. 1339: 13-25. PMID: 24661872
  8. Formaldehyde may be found in cosmetic products even when unlabelled.  |  Malinauskiene, L., et al. 2015. Open Med (Wars). 10: 323-328. PMID: 28352713
  9. A Direct Assay for Measuring Free 25-Hydroxyvitamin D.  |  Heureux, N., et al. 2017. J AOAC Int. 100: 1318-1322. PMID: 28492143
  10. GDME-based methodology for the determination of free formaldehyde in cosmetics and hygiene products containing formaldehyde releasers.  |  Brandão, PF., et al. 2018. Anal Bioanal Chem. 410: 6873-6880. PMID: 30062513
  11. Alkylarylation of styrenes via direct C(sp3)-Br/C(sp2)-H functionalization mediated by photoredox and copper cooperative catalysis.  |  Yong, X., et al. 2018. Chem Commun (Camb). 54: 12816-12819. PMID: 30357170
  12. Potential for repurposing the personal care product preservatives bronopol and bronidox as broad-spectrum antibiofilm agents for topical application.  |  Lee, VE. and O'Neill, AJ. 2019. J Antimicrob Chemother. 74: 907-911. PMID: 30590494
  13. Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox).  |  Ghannoum, M., et al. 1986. Folia Microbiol (Praha). 31: 19-31. PMID: 3082729
  14. Indium controlled regioselective 1,4-alkylarylation of 1,3-dienes with α-carbonyl alkyl bromides and N-heterocycles.  |  Gu, CC., et al. 2020. Chem Commun (Camb). 56: 1279-1282. PMID: 31904057
  15. In vitro skin penetration of bronidox, bronopol and formaldehyde from cosmetics.  |  López-Sánchez, L., et al. 2021. Regul Toxicol Pharmacol. 122: 104888. PMID: 33577887

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Bromo-5-nitro-1,3-dioxane, 5 g

sc-254789
5 g
$121.00

5-Bromo-5-nitro-1,3-dioxane, 10 g

sc-254789A
10 g
$162.00

5-Bromo-5-nitro-1,3-dioxane, 100 g

sc-254789B
100 g
$222.00

Could you please inform the expiry date of the 5-Bromo-5-nitro-1,3-dioxane? Thank you

Asked by: Anonymous
All of our products are warrantied for one year from the date purchased. If a CoA with an expiration date is needed, please inquire with Technical Service and one will be provided to you. Please note that all CoAs are lot-specific.
Answered by: Technical Support
Date published: 2020-07-16

Hello. Are there any larger amounts offered?

Asked by: nastka
Thank you for your question. Please contact one of our Special Orders Coordinators to inquire about the availability of larger quantities for this chemical. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-08-18

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. 5-Bromo-5-nitro-1,3-dioxane: sc-254789 is expected to be a white to light yellow crystalline powder.
Answered by: Chemical Support 3
Date published: 2017-04-14

What is the recommended solubility?

Asked by: chemicalsmg
Thank you for your question. 5-Bromo-5-nitro-1,3-dioxane: sc-254789 is soluble in ethanol (25mg/ml), DMSO (30mg/ml), or DMF (30mg/ml).
Answered by: Chemical Support 3
Date published: 2017-04-14
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Rated 5 out of 5 by from Ghannoum M; et alGhannoum M; et al. (PubMed ID: 3082729) determined that 5-Bromo-5-nitro-1,3-dioxane causes oxidation of an essential protein thus causing enzyme activity inhibition in microbes. -SCBT Publication Review
Date published: 2015-05-29
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5-Bromo-5-nitro-1,3-dioxane is rated 5.0 out of 5 by 1.
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