Date published: 2025-11-20

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1,2-Diethylbenzene (CAS 135-01-3)

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Application:
1,2-Diethylbenzene is a building block for synthesis
CAS Number:
135-01-3
Molecular Weight:
134.22
Molecular Formula:
C10H14
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Diethylbenzene is an organic compound that finds extensive use in research, particularly within the areas of synthetic chemistry and materials science. It serves as a starting material for the synthesis of various polymers and fine chemicals, where its diethyl substituents can be leveraged to introduce steric bulk or to modify the electronic properties of resulting compounds. In catalysis research, 1,2-diethylbenzene is often used as a model substrate to study the mechanisms of catalytic reactions involving the selective transformation of substituted benzenes. Furthermore, it is involved in the study of degradation pathways of volatile organic compounds in the atmosphere, aiding in the understanding of environmental impact and outcome of these compounds. Researchers also utilize 1,2-diethylbenzene in the development of new organic electronic materials, where its structure may contribute to the tuning of charge transport properties.


1,2-Diethylbenzene (CAS 135-01-3) References

  1. Assessment of the developmental toxicity and placental transfer of 1,2-diethylbenzene in rats.  |  Saillenfait, AM., et al. 1999. Food Chem Toxicol. 37: 1089-96. PMID: 10566880
  2. Toxicokinetics of 1,2-diethylbenzene in male Sprague-Dawley rats-part 1: excretion and metabolism of [(14)C]1,2-diethylbenzene.  |  Payan, JP., et al. 1999. Drug Metab Dispos. 27: 1470-8. PMID: 10570029
  3. Toxicokinetics and metabolism of 1,2-diethylbenzene in male Sprague Dawley rats--part 2: evidence for in vitro and in vivo stereoselectivity of 1,2-diethylbenzene metabolism.  |  Payan, JP., et al. 2001. Drug Metab Dispos. 29: 868-76. PMID: 11353756
  4. Aromatic as well as aliphatic hydrocarbon solvent axonopathy.  |  Spencer, PS., et al. 2002. Int J Hyg Environ Health. 205: 131-6. PMID: 12018006
  5. A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male rat.  |  Thrall, KD., et al. 2007. J Toxicol Environ Health A. 70: 67-72. PMID: 17162499
  6. Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells.  |  Kim, MK., et al. 2007. J Toxicol Environ Health A. 70: 1336-43. PMID: 17654252
  7. Using supercritical fluid chromatography to determine diffusion coefficients of 1,2-diethylbenzene, 1,4-diethylbenzene, 5-tert-butyl-m-xylene and phenylacetylene in supercritical carbon dioxide.  |  Pizarro, C., et al. 2007. J Chromatogr A. 1167: 202-9. PMID: 17850810
  8. Bio-distribution study of 1,2-diethylbenzene and its main metabolites by whole-body autoradiography and tissue homogenates.  |  Payan, JP., et al. 2008. Arch Toxicol. 82: 591-600. PMID: 18253718
  9. Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene.  |  Tshala-Katumbay, D., et al. 2008. Toxicol Sci. 105: 134-41. PMID: 18502740
  10. Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats.  |  Gagnaire, F., et al. 1991. J Appl Toxicol. 11: 261-8. PMID: 1939999
  11. Diethylbenzene-induced sensorimotor neuropathy in rats.  |  Gagnaire, F., et al. 1990. J Appl Toxicol. 10: 105-12. PMID: 2362075
  12. Olfactory mucosal necrosis in rats following acute intraperitoneal administration of 1,2-diethylbenzene, 1,2-diacetylbenzene and 2,5-hexanedione.  |  Gagnaire, F. and Boucard, S. 2014. Neurotoxicology. 41: 9-19. PMID: 24373906
  13. Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene.  |  Hoang, NMH., et al. 2021. Biomol Ther (Seoul). 29: 399-409. PMID: 33820880

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Diethylbenzene, 5 g

sc-253964
5 g
$210.00