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Sodium 4-methyl-2-oxovalerate (CAS 4502-00-5)

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Alternate Names:
Ketoleucine sodium salt; Sodium alpha-ketoisocaproate; 4-Methyl-2-oxopentanoic acid sodium salt
Application:
Sodium 4-methyl-2-oxovalerate is an inhibitor of pyruvate transport
CAS Number:
4502-00-5
Purity:
≥98%
Molecular Weight:
152.12
Molecular Formula:
C6H9O3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium 4-methyl-2-oxovalerate is a chemical compound that is used as an intermediate in the synthesis of various organic molecules. In biochemistry research, it is explored for its role as a precursor in the metabolism of branched-chain amino acids. This compound is involved in studies related to the catabolic pathways of leucine, an essential amino acid important for protein synthesis and energy production in muscle tissue. Researchers also employ sodium 4-methyl-2-oxovalerate in the study of metabolic disorders, including those involving branched-chain amino acid metabolism. In addition, it is used in the preparation of labeled compounds with stable isotopes, which are valuable in tracing metabolic pathways and enzyme mechanisms. Moreover, its utility in chemical synthesis extends to the production of specialty chemicals, where it can serve as a building block for more complex molecules.


Sodium 4-methyl-2-oxovalerate (CAS 4502-00-5) References

  1. Sensitive non-radioactive determination of aminotransferase stereospecificity for C-4' hydrogen transfer on the coenzyme.  |  Jomrit, J., et al. 2011. Biochem Biophys Res Commun. 405: 626-31. PMID: 21272566
  2. Kinetic characterization of recombinant Bacillus coagulans FDP-activated l-lactate dehydrogenase expressed in Escherichia coli and its substrate specificity.  |  Jiang, T., et al. 2014. Protein Expr Purif. 95: 219-25. PMID: 24412354
  3. Assessment of re-aggregated human pancreatic islets for secondary drug screening.  |  Ramachandran, K., et al. 2014. Br J Pharmacol. 171: 3010-22. PMID: 24641508
  4. Mitochondrial metabolites extend lifespan.  |  Mishur, RJ., et al. 2016. Aging Cell. 15: 336-48. PMID: 26729005
  5. A novel signal transduction protein: Combination of solute binding and tandem PAS-like sensor domains in one polypeptide chain.  |  Wu, R., et al. 2017. Protein Sci. 26: 857-869. PMID: 28168783
  6. Characterization and Synergistic Effect of Antifungal Volatile Organic Compounds Emitted by the Geotrichum candidum PF005, an Endophytic Fungus from the Eggplant.  |  Mookherjee, A., et al. 2018. Microb Ecol. 75: 647-661. PMID: 28894891
  7. Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression.  |  Ko, T., et al. 2020. Oncogene. 39: 723-738. PMID: 31548614
  8. Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.  |  Jansen, RS., et al. 2020. Nat Commun. 11: 1960. PMID: 32327655
  9. Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells.  |  Mann, G. and Adegoke, OAJ. 2021. Physiol Rep. 9: e14673. PMID: 33400857
  10. 2-Propylphenol Allosterically Modulates COQ8A to Enhance ATPase Activity.  |  Murray, NH., et al. 2022. ACS Chem Biol. 17: 2031-2038. PMID: 35904798
  11. A Nucleophilic Activity-Based Probe Enables Profiling of PLP-Dependent Enzymes.  |  Brody, SI., et al. 2023. Chembiochem. 24: e202200669. PMID: 36652345
  12. Intercellular pathway of leucine catabolism in rat spermatogenic epithelium.  |  Grootegoed, JA., et al. 1985. Biochem J. 226: 889-92. PMID: 3985949
  13. Bovine serum albumin decreases 4-methyl-2-oxovalerate utilization by isolated rat hepatocytes.  |  Livesey, G. 1983. Biochem J. 212: 655-8. PMID: 6882389

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium 4-methyl-2-oxovalerate, 250 mg

sc-253577A
250 mg
$33.00

Sodium 4-methyl-2-oxovalerate, 1 g

sc-253577
1 g
$67.00

Sodium 4-methyl-2-oxovalerate, 5 g

sc-253577B
5 g
$168.00

Sodium 4-methyl-2-oxovalerate, 25 g

sc-253577C
25 g
$496.00

Sodium 4-methyl-2-oxovalerate, 100 g

sc-253577D
100 g
$1244.00