Molecular structure of Bacitracin, CAS Number: 1405-87-4
Bacitracin (CAS 1405-87-4)
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Application:
Bacitracin is a peptide antibiotic and inhibitor of peptidoglycan synthesis
CAS Number:
1405-87-4
Molecular Weight:
1422.69
Molecular Formula:
C66H103N17O16S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bacitracin is a polypeptide antibiotic that is utilized extensively in microbiological research due to its ability to inhibit bacterial cell wall synthesis. It is particularly useful in studies that involve Gram-positive bacteria, where it serves as a tool to explore the bacterium′s cell wall biosynthesis pathways. In biochemistry, bacitracin is often used to investigate the role of peptidoglycan in maintaining cell wall integrity and to understand the mechanisms of antibiotic resistance. Additionally, this compound is employed in molecular biology as a selective agent in cell culture media to suppress unwanted bacterial contamination, thereby ensuring the growth of the desired cell lines or microorganisms. Research on bacitracin also includes investigation into its mode of action at the molecular level, which may provide insights into the development of new antibacterial strategies.
Bacitracin (CAS 1405-87-4) References
- Bacitracin production by the neotype; bacillus licheniformis ATCC 14580. | Haavik, HI. 1975. Acta Pathol Microbiol Scand Suppl. 83: 534-40. PMID: 1060363
- Effect of bacitracin on tetracycline resistance in Escherichia coli and Salmonella. | Lin, J., et al. 2009. Vet Microbiol. 138: 353-60. PMID: 19394165
- Bacitracin-conjugated superparamagnetic iron oxide nanoparticles: synthesis, characterization and antibacterial activity. | Zhang, W., et al. 2012. Chemphyschem. 13: 3388-96. PMID: 22753190
- Antibiotic bacitracin induces hydrolytic degradation of nucleic acids. | Ciesiołka, J., et al. 2014. Biochim Biophys Acta. 1840: 1782-9. PMID: 24508122
- Functional analysis of a bacitracin resistance determinant located on ICECp1, a novel Tn916-like element from a conjugative plasmid in Clostridium perfringens. | Han, X., et al. 2015. Antimicrob Agents Chemother. 59: 6855-65. PMID: 26282424
- Photooxidation of the Antimicrobial, Nonribosomal Peptide Bacitracin A by Singlet Oxygen under Environmentally Relevant Conditions. | Lundeen, RA., et al. 2016. Environ Sci Technol. 50: 8586-95. PMID: 27128169
- Biofunctionalization of titanium with bacitracin immobilization shows potential for anti-bacteria, osteogenesis and reduction of macrophage inflammation. | Nie, B., et al. 2016. Colloids Surf B Biointerfaces. 145: 728-739. PMID: 27289314
- Accelerated Stability Modeling for Peptides: a Case Study with Bacitracin. | Waterman, R., et al. 2017. AAPS PharmSciTech. 18: 1692-1698. PMID: 27714699
- Optimization of enhanced microbial production of zinc bacitracin by submerged fermentation technology. | Hassan, A., et al. 2020. J Basic Microbiol. 60: 585-599. PMID: 32364268
- Exploring antibiofilm potential of bacitracin against streptococcus mutans. | Zaidi, S., et al. 2020. Microb Pathog. 149: 104279. PMID: 32512154
- Proteomic Characterization and Target Identification Against Streptococcus mutans Under Bacitracin Stress Conditions Using LC-MS and Subtractive Proteomics. | Zaidi, S., et al. 2022. Protein J. 41: 166-178. PMID: 34989956
- Bacitracin and isothiocyanate functionalized silver nanoparticles for synergistic and broad spectrum antibacterial and antibiofilm activity with selective toxicity to bacteria over mammalian cells. | Singh, S. and Mishra, P. 2022. Biomater Adv. 133: 112649. PMID: 35034824
- 'Universal' Antimicrobial Combination of Bacitracin and His6-OPH with Lactonase Activity, Acting against Various Bacterial and Yeast Cells. | Aslanli, A., et al. 2022. Int J Mol Sci. 23: PMID: 36012663
- Protein expression profiling, in silico classification and pathway analysis of cariogenic bacteria Streptococcus mutans under bacitracin stress conditions. | Zaidi, S., et al. 2022. J Med Microbiol. 71: PMID: 36040855
- Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups. | Buijs, N., et al. 2022. Chembiochem. 23: e202200547. PMID: 36287040
Inhibitor of:
CBR4, CRS4C-2, cryptdin 24, cryptdin 25, cryptdin 26, cryptdin 4, DPAGT1, GRXCR1, OST48, PDI, PDI1 ER and Nuclear Envelope Marker, PDIA2, RmlB, Selenoprotein M, SLC15A solute carrier (SLC) group, TXNDC1, TXNDC10, and TXNDC14.Activator of:
ERAP2, PBP, and Vancomycin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bacitracin, 5 g | sc-252399 | 5 g | $87.00 |