Date published: 2025-11-2

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N,N-Dimethylacetamide (CAS 127-19-5)

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Alternate Names:
Acetic acid dimethylamide; N-Acetyldimethylamine
Application:
N,N-Dimethylacetamide is N,N-Dimethylacetamide is an organic compound that has been utilized as a non-polar solvent.
CAS Number:
127-19-5
Molecular Weight:
87.12
Molecular Formula:
C4H9NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N,N-Dimethylacetamide is an organic compound that has been utilized as a non-polar solvent. N,N-dimethylacetamide, known as DMAC, serves as a highly versatile organic solvent with various valuable attributes. This colorless liquid exhibits a non-volatile and relatively unreactive nature, making it an ideal choice for both industrial applications and scientific research endeavors. With a boiling point of approximately 140°C, a melting point of -17°C, and a density of 0.945 g/cm3, N,N-Dimethylacetamide boasts favorable physical properties. Its low vapor pressure and excellent miscibility with most common organic solvents further enhance its utility in diverse processes. In scientific research, N,N-Dimethylacetamide finds widespread use as a solvent for numerous organic reactions. It plays a pivotal role in synthesizing organic compounds, as well as extracting and purifying natural products. Moreover, it proves invaluable as a solvent in chromatography and electrophoresis techniques. Being a polar aprotic solvent, N,N-Dimethylacetamide possesses a low dielectric constant, enabling it to effectively solvate a wide range of organic compounds. This unique ability empowers N,N-Dimethylacetamide to play a stabilizing role with reactive intermediates during various organic reactions, contributing to its widespread application and importance in the scientific community.


N,N-Dimethylacetamide (CAS 127-19-5) References

  1. Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents.  |  Le Bras, J. and Muzart, J. 2018. Molecules. 23: PMID: 30081462
  2. Towards a coarse-grained model of the peptoid backbone: the case of N,N-dimethylacetamide.  |  Du, P., et al. 2018. Phys Chem Chem Phys. 20: 23386-23396. PMID: 30178791
  3. The Release of the Bromodomain Ligand N,N-Dimethylacetamide Adds Bioactivity to a Resorbable Guided Bone Regeneration Membrane in a Rabbit Calvarial Defect Model.  |  Siegenthaler, B., et al. 2020. Materials (Basel). 13: PMID: 31973011
  4. N, N-Dimethylacetamide, an FDA approved excipient, acts post-meiotically to impair spermatogenesis and cause infertility in rats.  |  Khera, N., et al. 2020. Chemosphere. 256: 127001. PMID: 32447106
  5. Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats.  |  Khera, N., et al. 2020. Front Physiol. 11: 601084. PMID: 33240111
  6. Reducing metal/graphene contact resistance via N, N-dimethylacetamide-assisted clean fabrication process.  |  Zhu, CY., et al. 2021. Nanotechnology. 32: PMID: 33882479
  7. Assessment of dermal exposure to N,N-dimethylacetamide in spray workers by combining personal exposure monitoring, biological monitoring, and glove permeation monitoring: A pilot study.  |  Yamamoto, S., et al. 2021. J Occup Health. 63: e12265. PMID: 34390065
  8. A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants.  |  Muzart, J. 2021. Molecules. 26: PMID: 34770783
  9. Increasing N,N-dimethylacetamide degradation and mineralization efficiency by co-culture of Rhodococcus ruber HJM-8 and Paracoccus communis YBH-X.  |  Yuan, B., et al. 2022. Chemosphere. 303: 134935. PMID: 35561776
  10. Achieving Highly Reversible Zinc Anodes via N, N-Dimethylacetamide Enabled Zn-Ion Solvation Regulation.  |  Wu, F., et al. 2022. Small. 18: e2202363. PMID: 35665600
  11. Mechanisms of N, N-dimethylacetamide-facilitated n-hexane removal in a rotating drum biofilter packed with bamboo charcoal-polyurethane composite.  |  Wang, Z., et al. 2023. Bioresour Technol. 372: 128600. PMID: 36634880
  12. Validation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of N,N-dimethylacetamide and N-monomethylacetamide in pediatric plasma.  |  Rosser, SPA., et al. 2023. J Sep Sci. 46: e2201003. PMID: 36879545
  13. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models.  |  Wei, ZH., et al. 2023. Sci Rep. 13: 7077. PMID: 37127686

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N,N-Dimethylacetamide, 100 ml

sc-250514A
100 ml
$40.00

N,N-Dimethylacetamide, 250 ml

sc-250514B
250 ml
$60.00

N,N-Dimethylacetamide, 1 L

sc-250514
1 L
$100.00

N,N-Dimethylacetamide, 4 L

sc-250514C
4 L
$310.00