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Cyclohexylamine (CAS 108-91-8)

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Alternate Names:
Aminocyclohexane
CAS Number:
108-91-8
Molecular Weight:
99.17
Molecular Formula:
C6H13N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cyclohexylamine is an organic compound that is a primary amine, signifying it consists of a six-membered carbon ring with a single nitrogen atom attached. This colorless liquid carries a distinctive amine-like scent and can mix with water. It is employed in the creation of polyurethane and polyurea, as well as in the synthesis of various organic compounds like dyes. Additionally, industrial processes utilize cyclohexylamine as a corrosion inhibitor. The compound′s use extends to numerous scientific research applications, including the synthesis of polymers. Being a primary amine, cyclohexylamine can function as a base, donating a proton to form a new bond in a reaction known as nucleophilic substitution, which is the process by which it interacts with other molecules. Moreover, cyclohexylamine can act as a nucleophile, taking a proton to create a new bond in a process called electrophilic addition, another mechanism by which it reacts with other molecules.


Cyclohexylamine (CAS 108-91-8) References

  1. Biodegradation of cyclohexylamine by Brevibacterium oxydans IH-35A.  |  Iwaki, H., et al. 1999. Appl Environ Microbiol. 65: 2232-4. PMID: 10224025
  2. The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.  |  Buss, NE., et al. 1992. Toxicol Appl Pharmacol. 115: 199-210. PMID: 1379387
  3. Ultra-trace level analysis of morpholine, cyclohexylamine, and diethylaminoethanol in steam condensate by gas chromatography with multi-mode inlet, and flame ionization detection.  |  Luong, J., et al. 2012. J Chromatogr A. 1229: 223-9. PMID: 22325017
  4. The morphogenesis of cyclohexylamine-induced testicular atrophy in the rat: in vivo and in vitro studies.  |  Creasy, DM., et al. 1990. Exp Mol Pathol. 52: 155-69. PMID: 2332033
  5. The pharmacokinetics and tissue concentrations of cyclohexylamine in rats and mice.  |  Roberts, A. and Renwick, AG. 1989. Toxicol Appl Pharmacol. 98: 230-42. PMID: 2469137
  6. Complete genome sequence of the cyclohexylamine-degrading Pseudomonas plecoglossicida NyZ12.  |  Li, X., et al. 2015. J Biotechnol. 199: 29-30. PMID: 25701176
  7. Metabolism of cyclamate and its conversion to cyclohexylamine.  |  Collings, AJ. 1989. Diabetes Care. 12: 50-5; discussion 81-2. PMID: 2714172
  8. Genome-wide identification and characterization of genes encoding cyclohexylamine degradation in a novel cyclohexylamine-degrading bacterial strain of Pseudomonas plecoglossicida NyZ12.  |  Yan, DZ., et al. 2017. J Biotechnol. 251: 166-173. PMID: 28472672
  9. Cyclohexylamine inexplicably induces antennae loss in Formosan subterranean termites (Coptotermes formosanus Shiraki): cyclohexylamine hydrogen phosphate salts are novel termiticides.  |  Grimball, B., et al. 2017. Pest Manag Sci. 73: 2039-2047. PMID: 28485048
  10. Draft Genome Sequence of Cyclohexylamine-Degrading Strain Acinetobacter sp. YT-02 Isolated.  |  Yan, DZ., et al. 2018. Curr Microbiol. 75: 284-287. PMID: 29063968
  11. Cloning and characterization of four enzymes responsible for cyclohexylamine degradation from Paenarthrobacter sp. TYUT067.  |  Feng, K., et al. 2022. Protein Expr Purif. 198: 106136. PMID: 35760252
  12. Cyclohexylamine inhibits the adhesion of lymphocytic cells to human syncytiotrophoblast.  |  Douglas, GC., et al. 1995. Biochim Biophys Acta. 1266: 229-34. PMID: 7766708
  13. Quantification of cyclamate and cyclohexylamine in urine samples using high-performance liquid chromatography with trinitrobenzenesulfonic acid pre-column derivatization.  |  Casals, I., et al. 1996. J Chromatogr A. 750: 397-402. PMID: 8938395
  14. Cyclohexylamine additives for enhanced peptide separations in reversed phase liquid chromatography.  |  Cole, SR. and Dorsey, JG. 1997. Biomed Chromatogr. 11: 167-71. PMID: 9192111
  15. Reaction of cyclohexylamine with hypochlorite and enhancement of oxidation of plasma sulfhydryl groups by hypochlorite in vitro.  |  Hu, ML. and Tsai, HH. 1998. Food Chem Toxicol. 36: 755-9. PMID: 9737422

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cyclohexylamine, 25 ml

sc-239615
25 ml
$21.00