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8-Quinolinol hemisulfate salt (CAS 134-31-6)

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Alternate Names:
Oxyquinoline sulfate
Application:
8-Quinolinol hemisulfate salt is an antifungal, antibacterial, and anthelmintic salt
CAS Number:
134-31-6
Purity:
97%
Molecular Weight:
388.39
Molecular Formula:
C18H14N2O2•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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8-Quinolinol hemisulfate salt, with the CAS number 134-31-6, is a sulfate salt form of 8-quinolinol, a compound known for its chelating properties, particularly towards metal ions. This chemical structure consists of a quinoline ring system, which allows it to bind strongly to transition metals, forming stable complexes. This chelation ability is pivotal in its mechanism of action, as it can sequester metal ions, thereby inhibiting processes that are dependent on metal catalysis. In research environments, 8-quinolinol hemisulfate salt is extensively utilized in studies of metal-mediated reactions, such as those important in environmental chemistry and biochemistry. For instance, it is used to investigate the role of metal ions in aquatic systems where metal chelation can influence biological availability and toxicity. Additionally, this compound is employed in the synthesis of metal-quinolinol complexes, which are of interest due to their potential applications in materials science, such as in the development of organic light-emitting diodes (OLEDs) and other optoelectronic devices. The ability to form complexes with a variety of metals also makes 8-quinolinol hemisulfate salt a valuable tool in analytical chemistry for the detection and quantification of metal ions in samples. Through these diverse applications, the compound provides significant insights into both the fundamental and applied aspects of chemistry.


8-Quinolinol hemisulfate salt (CAS 134-31-6) References

  1. Cytotoxicity in pig hepatocytes induced by 8-quinolinol, chloramine-T and natamycin.  |  Martínez-Larrañaga, MR., et al. 2000. J Vet Pharmacol Ther. 23: 37-44. PMID: 10747241
  2. Antimicrobial activity of 8-quinolinol, its salts with salicylic acid and 3-hydroxy-2-naphthoic acid, and the respective copper (II) chelates in liquid culture.  |  GERSHON, H. and PARMEGIANI, R. 1963. Appl Microbiol. 11: 62-5. PMID: 13960592
  3. Prooxidant action of xanthurenic acid and quinoline compounds: role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2'-deoxyguanosine in DNA.  |  Murakami, K., et al. 2006. Biometals. 19: 429-35. PMID: 16841252
  4. Spectrophotometric determination of ruthenium with 8-quinolinol.  |  Hashitani, H., et al. 1969. Talanta. 16: 1553-9. PMID: 18960676
  5. Evidence of steric factors in the fungitoxic mechanisms of 8-quinolinol and its 5- and 7-halogenated analogues.  |  Gershon, H., et al. 1991. J Pharm Sci. 80: 542-4. PMID: 1941544
  6. Redox properties of 8-quinolinol and implications for its mode of action.  |  Chobot, V., et al. 2011. Nat Prod Commun. 6: 597-602. PMID: 21615015
  7. Synergistic antifungal action of 8-quinolinol and its bischelate with copper(II) and with mixed ligand chelates composed of copper(II), 8-quinolinol, and aromatic hydroxy acids.  |  Gershon, H., et al. 1989. J Pharm Sci. 78: 975-8. PMID: 2516124
  8. Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide.  |  Cámara-Sánchez, P., et al. 2022. Int J Mol Sci. 23: PMID: 36233074
  9. Evidence that the mechanisms of fungitoxicity of 8-quinolinol and its bischelate with copper(II) are different.  |  Gershon, H., et al. 1985. Can J Microbiol. 31: 707-10. PMID: 3935305
  10. Reversal of fungitoxicity of 8-quinolinols and their copper(II) bischelates. II. Reversal of the action of 8-quinolinol by DL-alpha-lipoic acid.  |  Gershon, H. and Shanks, L. 1981. Can J Microbiol. 27: 612-26. PMID: 6790147

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Quinolinol hemisulfate salt, 100 g

sc-239132
100 g
$98.00